Sonderforschungsbereich 688 (2006-2017)

    Publikationen 2014



      1. Albert-Weissenberger C, Mencl S, Schuhmann MK, Salur I, Göb E, Langhauser F, Hopp S, Hennig N, Meuth SG, Nolte MW, Sirén AL, Kleinschnitz C. 2014. C1-Inhibitor protects from focal brain trauma in a cortical cryolesion mice model by reducing thrombo-inflammation. Front Cell Neurosci 8:269. doi: 10.3389/fncel.2014.00269. PMID: 25249935 (TP A13)
      2. Bender M, Stritt S, Nurden P, van Eeuwijk JM, Zieger B, Kentouche K, Schulze H, Morbach H, Stegner D, Heinze K, Dütting S, Gupta S, Witke W, Falet H, Fischer A, Hartwig JH, Nieswandt B. Megakaryocyte-specific Profilin1-deficiency alters microtubule stability and causes a Wiskott-Aldrich syndrome-like platelet defect. Nat Commun. 2014 Sep 4;5:4746. doi: 10.1038/ncomms5746.  PubMed PMID: 25187265 (TP B07)
      3. Busch M, Westhofen TC, Koch M, Lutz MB, Zernecke A. Dendritic cell subset distributions in the aorta in healthy and atherosclerotic mice. PLoS One. 2014 Feb 14;9(2):e88452. PMID: 24551105 (TP A22)
      4. Chen W, Thielmann I, Gupta S, Subramanian H, Stegner D, van Kruchten R, Dietrich A, Gambaryan S, Heemskerk JW, Hermanns HM, Nieswandt B, Braun A. Orai1-induced store-operated Ca(2+) entry enhances phospholipase activity and modulates canonical transient receptor potential channel 6 function in murine platelets. J Thromb Haemost. 2014 Apr;12 (4):528-39 PubMed 24520961. (TP A18)
      5. Cochain C, Chaudhari SM, Koch M, Wiendl H, Eckstein HH, Zernecke A. Programmed cell death-1 deficiency exacerbates T cell activation and atherogenesis despite expansion of regulatory T cells in atherosclerosis-prone mice. PLoS One. 2014 Apr 1;9(4):e93280. doi: 10.1371/journal.pone.0093280. PMID: 24691202 (TP A22)
      6. Gelderblom M, Melzer N, Schattling B, Göb E, Hicking G, Arunachalam P, Bittner S, Ufer F, Herrmann AM, Bernreuther C, Glatzel M, Gerloff C, Kleinschnitz C, Meuth SG, Friese MA, Magnus T. 2014. Transient Receptor Potential Melastatin Subfamily Member 2 Cation Channel Regulates Detrimental Immune Cell Invasion in Ischemic Stroke. Stroke pii: STROKEAHA.114.005836. PMID: 25236871 (TP A13)
      7. Israel I, Richter D, Stritzker J, van Ooschot M, Donat U, Buck AK, Samnick S. PET imaging with [68Ga]NOTA-RGD for prostate cancer: a comparative study with [18F]fluorodeoxyglucose and [18F]fluoroethylcholine. Curr Cancer Drug Targets. 2014 May;14(4):371-9. 24720338 (TP Z02)
      8. Kestler C, Knobloch G, Tessmer I, Jeanclos E, Schindelin H, Gohla A. Chronophin dimerization is required for proper positioning of its substrate specificity loop. J Biol Chem. 2014 Jan 31;289(5):3094-103. doi: 10.1074/jbc.M113.536482. Epub 2013 Dec 13. PMID: 24338687 (TP A11)
      9. Kraft P, Drechsler C, Gunreben I, Nieswandt B, Stoll G, Heuschmann PU, Kleinschnitz C. 2014. Von Willebrand factor regulation in patients with acute and chronic cerebrovascular disease: a pilot, case-control study. PLoS One 9(6):e99851. doi: 10.1371/journal.pone.0099851.PMID: 24937073 (TP A13)
      10. Kraft P, Drechsler C, Gunreben I, Heuschmann PU, Kleinschnitz C. 2014. Regulation of Blood Coagulation Factors XI and XII in Patients with Acute and Chronic Cerebrovascular Disease: a Case–Control Study. Cerebrovascular Diseases. PMID: 25427539 (TP A13)
      11. Langhauser F, Kraft P, Göb E, Leinweber J, Schuhmann MK, Lorenz K, Gelderblom M, Bittner S, Meuth SG, Wiendl H, Magnus T, Kleinschnitz C. 2014. Blocking of α4 integrin does not protect from acute ischemic stroke in mice. Stroke 45(6):1799-806. doi: 10.1161/STROKEAHA.114.005000. PMID: 24743435 (TP A13)
      12. Li X, Bauer W, Israel I, Kreissl MC, Weirather J, Richter D, Bauer E, Herold V, Jakob P, Buck A, Frantz S, Samnick S. Targeting P-Selectin by Gallium-68-Labeled Fucoidan Positron Emission Tomography for Noninvasive Characterization of Vulnerable Plaques: Correlation With In Vivo 17.6T MRI. Arterioscler Thromb Vasc Biol, 2014, in press PMID: 24903095 (TP Z02 / B04/B05 / A10)
      13. Mencl S, Hennig N, Hopp S, Schuhmann MK, Albert-Weissenberger C, Sirén AL, Kleinschnitz C. 2014. FTY720 does not protect from traumatic brain injury in mice despite reducing posttraumatic inflammation.  J Neuroimmunol 274(1-2):125-31. doi: 10.1016/j.jneuroim.2014.07.010. PMID: 25081505 (TP A13)
      14. Mischnik M, Gambaryan S, Subramanian H, Geiger J, Schütz C, Timmer J, Dandekar T. A comparative analysis of the bistability switch for platelet aggregation by logic ODE based dynamical modeling. Mol Biosyst. 2014 Jul 1;10(8):2082-2089.PubMed PMID: 24852796 (TP A02)
      15. Schuhmann MK, Kraft P, Stoll G, Lorenz K, Meuth SG, Wiendl H, Nieswandt B, Sparwasser T, Beyersdorf N, Kerkau T, Kleinschnitz C. 2014. CD28 superagonist-mediated boost of regulatory T cells increases thrombo-inflammation and ischemic neurodegeneration during the acute phase of experimental stroke. JCBFM. In press PMID: 25315859 (TP A13)
      16. Seifried A, Knobloch G, Duraphe PS, Segerer G, Manhard J, Schindelin H, Schultz J, Gohla A. Evolutionary and structural analyses of mammalian haloacid dehalogenase-type phosphatases AUM and chronophin provide insight into the basis of their different substrate specificities. J Biol Chem. 2014 Feb 7;289(6):3416-31. doi: 10.1074/jbc.M113.503359. Epub 2013 Dec 13. PMID: 24338473 (TP A11)
      17. Simsekyilmaz S, Cabrera-Fuentes HA, Meiler S, Kostin S, Baumer Y, Liehn EA, Weber C, Boisvert WA, Preissner KT, Zernecke A. Role of extracellular RNA in atherosclerotic plaque formation in mice. Circulation. 2014 Feb 4;129(5):598-606. PMID: 25311624 (TP A22)
      18. Stefanovic, S., Barnett, P., van Duijvenboden, K., Weber, D., Gessler, M., and Christoffels, V. M. (2014). GATA-dependent regulatory switches establish atrioventricular canal specificity during heart development. Nat Commun 5, 3680 PubMed PMID 24770533. (TP A16)
      19. Stegner D, Dütting S, Nieswandt B. Mechanistic explanation for platelet contribution to cancer metastasis. Thromb Res. 2014 May;133 Suppl 2:S149-57. PubMed PMID 24862136  (A01/B07)
      20. Stegner D, Haining EJ, Nieswandt B. Targeting glycoprotein VI and the immunoreceptor tyrosine-based activation motif signaling pathway. Arterioscler Thromb Vasc Biol. 2014 Aug;34(8):1615-20. PubMed PMID 24925975 (TP A01/B07)
      21. Stritt S, Thielmann I, Duetting S, Stegner D, Nieswandt B. Phospholipase D is a central regulator of collagen I-induced cytoskeletal rearrangement and podosome formation in megakaryocytes. J Thromb Haemost 2014; 12: 1364–71. PMID: 24909796 (TP A01)
      22. Zernecke A, Weber C. Chemokines in atherosclerosis: proceedings resumed. Arterioscler Thromb Vasc Biol. 2014 Apr;34(4):742-50 PMID: 24436368 (TP A22)
      23. Zernecke A. Distinct functions of specialized dendritic cell subsets in atherosclerosis and the road ahead. Scientifica (Cairo). 2014;2014:952625 PMID: 24818041 (TP A22)