An international team from the field of immunology has been awarded one of the most highly endowed research grants in the EU: the ERC Synergy Grant. Its aim is to explore new possibilities for immunotherapy of liver metastases.
The four scientists conduct research in Italy, France and Germany. They are each considered leaders in their field.
Valeria Fumagalli is an expert in liver immunology and works with tissue samples from tumor patients at the San Raffaele Hospital in Milan.
Florent Ginhoux from the Gustave Roussy Cancer Campus in Paris is an expert in the biology of myeloid cells and how they function in healthy and diseased tissue.
Georg Gasteiger's work focuses on lymphocytes of the innate immune system, including so-called "natural killer" or NK cells, and how they develop and function in the different tissues of the body.
Eric Vivier from the Centre d'Immunologie in Marseille-Luminy has already developed several molecules with which these cells can be activated to fight tumor cells - and successfully brought them into clinical trials on patients.
Based on this experience, the team wants to develop new approaches to immunotherapy.