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Research

Collaborative Research Centers

Collaborative Research Centers

Infectious diseases are a major cause of suffering, morbidity and mortality worldwide. In particular, the worldwide increase of multidrug-resistant pathogens and the constant emergence of new human pathogens pose immense challenges to modern medicine. The Collaborative Research Centre 1583 "Decisions in Infectious Diseases" aims to identify molecular mechanisms within the host that control the course of infectious diseases. In particular it focuses on key decisions, which determine the clinical outcome of human infections.

Location: Würzburg

Speaker: Prof. Dr. Thomas Rudel (Faculty of Biology)

Duration: starting 2023

Further information can be found here.

The latest research on myocardial diseases shows that inflammatory and immunological mechanisms influence the performance of the heart. Depending on the context and time, for example in the case of a heart attack, they can have both positive and negative effects. The Collaborative Research Center 1525 "Cardio-immune Interfaces" wants to elucidate the interactions between these mechanisms and heart diseases and thus create the basis for new therapies.

Location: Würzburg

Speaker: Prof. Dr. Stefan Frantz (Medical Faculty)

Duration: since 2022

Further information can be found here.

The SFB 1170 "Topological and Correlated Electronics at Surfaces and Interfaces" combines two of the most active and interesting research fields in modern solid state physics: topological phases and strong electronic correlations.

Location: Würzburg

Speaker: Prof. Dr. Björn Trauzettel (Faculty of Physics and Astronomy)

Duration: since 2015

Further information can be found here.

CRC/Transregio (TRR)

Adoptive T-cell therapy represents a promising, rapidly developing field of translational medical research. The Collaborative Research Center/Transregio 338 "LETSIMMUN", which is jointly funded by the TU Munich, the LMU Munich and the JMU, wants to be a national hot spot for the most modern basic and translational research in the field of "lymphocyte engineering" and aims to provide novel concepts and cell products for clinical development that offer therapeutic synthetic immunity for patients.

Locations: Munich, Würzburg

Speaker: Prof. Dr. Dirk Busch (TU Munich)

Speaker in Würzburg: Prof. Dr. Hermann Einsele (Medical Faculty)

Duration: since 2021

Further information can be found here.

The aim of the CRC/TRR 295, which is jointly run by the Charité Berlin and the JMU, is to understand the diverse symptoms of motor network diseases by characterizing symptom-specific network activity and to use these findings for the development of innovative neuromodulation strategies for the therapy of common and clinically relevant movement disorders.

Locations: Berlin, Würzburg

Speaker: Prof. Dr. Andrea Kühn (Charité Berlin)

Speaker in Würzburg: Prof. Dr. Jens Volkmann (Medical Faculty)

Duration: since 2020

Further information can be found here.

The aim of the DFG-funded CRC/TRR 240 is to decode the complex and poorly understood functions of blood platelets, the so-called thrombocytes. The scientists within this project hope for new insights that will enable better treatment of diseases such as heart attacks, strokes, acute lung failure and cancer.

Locations: Würzburg, Tübingen

Speaker: Prof. Dr. Bernhard Nieswandt (Medical Faculty)

Duration: since 2018

Further information can be found here.

The objective of CRC/TRR 225 are investigations into the basics of biofabrication and its systematic use, with the aim of generating functional human tissue models (12-year perspective). Based on the available expertise at the participating locations in the field of biofabrication, the aim is to create with the CRC/TRR 225 and complementary state funding (Bavarian Polymer Institute) a sustainable competence center with a leading international role.

Locations: Würzburg, Bayreuth, Erlangen

Speaker: Prof. Dr. Jürgen Groll (Medical Faculty)

Duration: since 2018

Further information can be found here.

Within the Collaborative Research Center/Transregio 221, physicians and scientists from the Universities of Regensburg, Erlangen-Nuremberg and Würzburg as well as their respective university hospitals are aiming to find ways to make allogeneic stem cell transplantation safer and more successful in the future by avoiding disease relapses and reducing transplantation complications.

Locations: Regensburg, Erlangen, Würzburg

Speaker: Prof. Dr. Wolfgang Heer (Universität Regensburg)

Speaker in Würzburg: Prof. Dr. Hermann Einsele (Medical Faculty)

Duration: since 2018

Further information can be found here.

The CRC/TRR 205 unites several institutes in Dresden, Munich and Würzburg, with the aim to investigate the fundamental role of the adrenal gland in functional disorders, tumors and systemic diseases. The development of new diagnostic and therapeutic strategies for the treatment of adrenal gland diseases and the associated frequent stress-related diseases is of great importance for the well-being of the individual patient as well as for society as a whole.

Locations: Dresden, Munich, Würzburg

Speaker: Prof. Dr. Stefan R. Bornstein (Technische Universität Dresden)

Speaker in Würzburg: Prof. Dr. Martin Fassnacht (Medical Faculty)

Duration: since 2017

Further information can be found here.

The CRC/TRR 124 bundles the expertise into human pathogenic fungi at the sites in Jena and Würzburg. Life-threatening fungal infections have increased dramatically over the past two decades. These infections are hardly curable, especially in high-risk patients. The diagnostic options are limited and the diagnosis is often made too late. To make matters worse, current options for antifungal therapy are limited. The polymorphic yeast Candida albicans and the filamentous fungus Aspergillus fumigatus cause by far the most cases of invasive fungal infections in Europe.

Locations: Jena, Würzburg

Speaker: Prof. Dr. Axel Brakhage (Friedrich-Schiller-Universität Jena)

Speaker in Würzburg: Prof. Dr. Hermann Einsele (Medical Faculty)

Duration: 2013-2025

Further information can be found here.

Collaborative Research Centers with participation of JMU

Autoimmune diseases are chronic inflammatory diseases that affect around 8% of the population in industrialized countries. Current therapies for autoimmune diseases are only partially effective, mostly based on unselective immunosuppression and can be associated with serious side effects. The SFB 1526 investigates the development of antibody-mediated autoimmune diseases with the aim of developing new strategies for the diagnosis and treatment of these diseases.

Locations: Lübeck, Kiel, Erlangen-Nuremberg, Würzburg

Speaker: Prof. Dr. Christian David Sadik (Universität zu Lübeck)

Duration: since 2022

Further information can be found here.

Chronic pathological pain is a global problem for our healthcare systems and a challenge for both basic and clinical research. One obstacle is the insufficient elucidation of the neural basis of the complex and multidimensional pain process as well as the various maladaptive plasticity mechanisms. In addition, chronic pain is associated with many comorbid mental disorders. The primary goal of the CRC 1158 is to understand the structure-function relationships of cells, circuits and networks and to analyze how these are changed during the transition from acute to chronic pain.

Locations: Bonn, Heidelberg, Saarbrücken, Würzburg

Speaker: Prof. Dr. Rohini Kuner (Ruprecht-Karls-Universität Heidelberg)

Duration: since 2015

Further information can be found here.

The CRC 1066 investigates the use of nanoparticulate drug carriers (NP) in tumor immunotherapy. Novel polymer- and lipid-based NP are being synthesized, chemically characterized and their application in complex biological systems is being investigated from bench to bedside. The aim is to activate the immune system of tumor patients in such a way that tumors can effectively be recognized and destroyed by the body's own immune defense.

Locations: Saarbrücken, Würzburg

Speaker: Prof. Dr. Stephan Grabbe (Johannes Gutenberg-Universität Mainz)

Duration: 2013-2025

Further information can be found here.

Receiving, processing and forwarding information is one of the elementary functions of higher organisms. One of the most important signaling molecules are Ca2+ ions, the concentration of which is kept at a low level in the cytosol of a cell. The CRC 894 investigates the Ca2+ signals across a broad spectrum: from the molecular mechanisms of their formation to their integrative effect on the whole body. The future goal is to investigate the importance of subcellular Ca2+ signals with regard to the physiological behavior of entire organs.

Locations: Saarbrücken, Würzburg

Speaker: Prof. Dr. Veit Flockerzi (University Hospital of the Saarland)

Duration: 2011-2022

Further information can be found here.