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English Intern
Rudolf-Virchow-Zentrum - Center for Integrative and Translational Bioimaging

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The Rudolf Virchow Center for Integrative and Translational Bioimaging (RVZ) is a multidisciplinary research institute of the University of Würzburg, Germany. RVZ scientists perform innovative basic and translational research with a focus on state-of-the-art imaging technologies. The group of Dr. Tamara Girbl invites applications for a

Postdoc Position (f/m/d) in Immunology and Vascular Biology

Our main goal is to understand the cellular and molecular mechanisms of immune cell migration across blood vessel walls. During an immune response circulating leukocytes need to pass i) the endothelium and ii) pericyte layer of vascular walls to enter tissue compartments. However, very little is known about the interaction of leukocytes with venular pericytes (see Girbl, et al., Immunity 2018).

Job description: The successful candidate will investigate the cellular and molecular mechanisms of T lymphocyte – pericyte interactions and their effect on physiological and pathological immune responses. The approach applies intravital confocal and multiphoton microscopy, RNA sequencing, in situ hybridization and mouse models of acute and chronic inflammation (e.g. in the skin). In vivo methods will be complemented by cell culture, immunological and molecular biological techniques (e.g. flow cytometry/FACS) and human tissue samples to study the implications of our findings in human diseases.

Your qualifications:

  • PhD in life sciences with focus on immunology, vascular biology, or cell adhesion/migration (candidates in final stage of obtaining their degree are eligible to apply)
  • Experience with handling/dissecting mice is essential
  • Practical experience in fluorescence microscopy is required
  • Very good knowledge in flow cytometry or cell sorting
  • Experience in RNA sequencing or in situ hybridization is a plus
  • Evidence of good productivity through publications
  • Excellent communication, organizational and presentation skills
  • Ability to work independently and a part of a team
  • Proficiency in written and spoken English is mandatory

We offer:

  • An international, collaborative and family friendly working environment
  • Excellent infrastructure including cutting edge imaging facilities
  • Training opportunities for technical and transferable skills
  • A comprehensive pension scheme
  • Childcare facilities

The position is available immediately or upon mutual agreement on a full-time basis for 3 years initially. Part-time is possible. The salary will be according to the collective bargaining agreement (TV-L). Disabled applicants will be preferentially considered in case of equivalent qualifications.

Please submit your application, including a single page motivation letter (stating your soonest availability for the position), your CV, list of publications and contact details of two referees as single PDF (≤10 MB) to Dr. Tamara Girbl tamara.girbl@uni-wuerzburg.de. The closing date is July 14th 2021.

Rudolf-Virchow-Zentrum – Center for Integrative and Translational Bioimaging
Universität Würzburg
Dr. Tamara Girbl
Josef-Schneider-Str. 2/Haus D15
D-97080 Würzburg
https://www.uni-wuerzburg.de/rvz/startseite/

For further information please visit:
https://www.uni-wuerzburg.de/rvz/forschung/forschungsgruppen/ag-girbl/
https://www.sciencedirect.com/science/article/pii/S1074761318304333?via%3Dihub

The Rudolf Virchow Center for Integrative and Translational Bioimaging (RVZ) is a multidisciplinary research institute of the University of Würzburg, Germany. RVZ scientists perform innovative basic and translational research with a focus on state-of-the-art imaging technologies. The group of Dr. José Pedro Friedmann Angeli invites applications for

1 PhD Position (f/m/d) in Cell Death and Cancer Metabolism

Our main goal is to understand the process that allow cells to cope and adapt to oxidative stress with a particular focus on a cell death modality known as ferroptosis. Ferroptosis has amassed increased attention as a strategy to kill tumor entities and states that challenge current treatments strategies. In our group we aim to explore and identify basic mechanism regulating ferroptosis and leverage them in the context of selected malignancies such as adrenocortical carcinomas and multiple myeloma.

Job description: The successful candidate will investigate the cellular and molecular mechanisms of ferroptosis and explore pharmacological and antibody based strategies to inhibit this pathways in relevant settings. For this, the applicant will apply functional genetics methodologies such as CRISPR/Cas9 screen and additional methods including RNA sequencing, tumor mouse model (genetic and xenografts), metabolomics and protein biochemistry.

Your qualifications:

  • Master in life sciences with focus on redox biology, oncology, mouse models or metabolism
  • Experience with handling/dissecting mice is favourable
  • Practical experience in molecular biology is required
  • Good knowledge in flow cytometry and cell sorting
  • Experience in RNA sequencing and basic programing is a plus
  • Excellent communication, organizational and presentation skills
  • Ability to work independently and as part of a team
  • Proficiency in written and spoken English is mandatory, a good level of German would be beneficial

We offer:

  • An international, collaborative and family friendly working environment
  • Excellent infrastructure including cutting edge facilities
  • Training opportunities for technical and transferable skills
  • A comprehensive pension scheme
  • Childcare facilities

The position is available immediately or upon mutual agreement for 3 years initially. The salary will be according to the collective bargaining agreement (TV-L, 65%). Disabled applicants will be preferentially considered in case of equivalent qualifications.

Please submit your application, including a single page motivation letter (stating your soonest availability for the position), your CV, list of publications and contact details of two referees as single PDF (less than10 MB) to Dr. José Pedro Friedmann Angeli pedro.angeli@uni-wuerzburg.de. The position will remain open until it is filled.

Rudolf-Virchow-Zentrum – Center for Integrative and Translational Bioimaging
Universität Würzburg
Dr. José Pedro Friedmann Angeli
Josef-Schneider-Str. 2/Haus D15
D-97080 Würzburg

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