Rudolf-Virchow-Zentrum - Center for Integrative and Translational Bioimaging


Super-resolution imaging can identify, quantify and map elongated periodic protein distances and protein interaction in histopathological tissue samples. Here, we combine high-content and super-resolution translational imaging to interrogate the modifications of molecular architecture underlying polyneuropathies in patients.


Super-resolution imaging pinpoints the periodic ultrastructure at the human node of Ranvier and its disruption in patients with polyneuropathy. Appeltshauser L, Linke J, Heil HS, Karus C, Schenk J, Hemmen K, Sommer C, Doppler K*, Heinze KG*. Neurobiol Dis. 2023 Jun 15;182:106139. doi: 10.1016/j.nbd.2023.106139. *corresponding author

Anti-pan-neurofascin antibodies induce subclass-related complement activation and nodo-paranodal damage. Appeltshauser L, Junghof H, Messinger J, Linke J, Haarmann A, Ayzenberg I, Baka P, Dorst J, Fisse AL, Grüter T, Hauschildt V, Jörk A, Leypoldt F, Mäurer M, Meinl E, Michels S, Motte J, Pitarokoili K, Stettner M, Villmann C, Weihrauch M, Welte GS, Zerr I, Heinze KG, Sommer C, Doppler K.
Brain. 2023 May 2;146(5):1932-1949. doi: 10.1093/brain/awac418.PMID: 36346134