Screening Facility
Small molecules are central to exploring the intricacies of biological systems and advancing our understanding of life sciences. To identify such molecules High Throughput Screening (HTS) allows researchers to quickly conduct thousands of tests against a biological target. The Screening Facility at the Rudolf-Virchow-Center harboring compound libraries in total of over 25.000 compounds for different screening tasks. In addition, the screening facility manages divers robotic liquid handling systems (ECHO, Opentron Flex, Agilent 406FX) and a diverse portfolio on screening methods and readouts.
The screening facility provides:
- Assisting in assay development, for selection of an appropriate assay readout
- Assessing the compatibility of the target assay with automation and high-throughput screening
- Developing and optimizing assays for high-throughput screening
- Conducting of HTS campaigns for biochemical, cell-based and protein-protein assays
- Conducting Fragment Screenings using a diverse biophysical portfolio (GCI, BLI, ligand-based NMR, X-ray)
- Assisting in follow up of hits with reporting of EC50/IC50 and solubility data
- Cell culture for cell-based assay targets and screening campaigns
- Assisting in biophysical question of small molecule protein interactions
- DEL-Screening in collaboration with the Brunschweiger research group at the Institute of Pharmacy
- In silico-Screening in collaboration with the Sotriffer research group at the Institute of Pharmacy
The Screening Facility is available to research groups at the University of Würzburg, as well as (by arrangement) to external users. Please note our rules of use and price list.
