Chair of Microbiology
Biocenter, University of Würzburg
Tel.: 0931 31 84401
Fax: 0931 31 84402
Infection Biology, Molecular and Cellular Microbiology
Due to an obligate intracellular lifestyle, pathogenicity mechanisms of Chlamydia trachomatis have been very difficult to investigate. The group of Thomas Rudel engineers a vascularized infection model using cervical and Fallopian tube epithelial cells. Since N. gonorrhoeae and Chlamydia infections frequently co-occur in patients and infect the same tissue, this infection model is developed together with the group of Vera Kozjak-Pavlovic. Gene regulation in the infection model will be investigated by dual RNA-Seq (partner Jörg Vogel). Raman Spectroscopy will be used to study the cross-talk of Chlamydia with primary host cells (partner Maria Steinke). A focus will be the innate immune response and metabolic reprogramming of host cells that allows Chlamydia to establish a successful infection.