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Intern
    Graduiertenkolleg 2157

    Prof. Dr. Thomas Rudel

    Chair of Microbiology
    Biocenter, University of Würzburg
    Am Hubland
    D-97074 Würzburg

    Tel.: 0931 31 84401
    Fax: 0931 31 84402

    Email: thomas.rudel@biozentrum.uni-wuerzburg.de
    Web: www.mikrobio.biozentrum.uni-wuerzburg.de


    Research area:
    Infection Biology, Molecular and Cellular Microbiology

    Due to an obligate intracellular lifestyle, pathogenicity mechanisms of Chlamydia trachomatis have been very difficult to investigate. The group of Thomas Rudel engineers a vascularized infection model using cervical and Fallopian tube epithelial cells. Since N. gonorrhoeae and Chlamydia infections frequently co-occur in patients and infect the same tissue, this infection model is developed together with the group of Vera Kozjak-Pavlovic. Gene regulation in the infection model will be investigated by dual RNA-Seq (partner Jörg Vogel). Raman Spectroscopy will be used to study the cross-talk of Chlamydia with primary host cells (partner Maria Steinke). A focus will be the innate immune response and metabolic reprogramming of host cells that allows Chlamydia to establish a successful infection.