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Intern
    Graduiertenkolleg 2157

    Prof. Dr. Alexandra Schubert-Unkmeir

    Institute for Hygiene and Mikrobiology
    University of Würzburg
    Josef-Schneider-Straße 2
    D-97080 Würzburg

    Tel.: 0931 31 46721
    Fax: 0931 31 46445

    Email: aunkmeir@hygiene.uni-wuerzburg.de
    Web: www.hygiene.uni-wuerzburg.de/forschung/ag_schubert_unkmeir


    Research Area:
    Infection Biolgy, Molecular and Cellular Microbiology

    Neisseria meningitidis can cross the epithelium of the nasopharynx, gain access to the bloodstream and cause severe septicemia and/or meningitis. In the case of invasive meningococcal diseases endothelial adhesion events must occur during circulation under conditions of physiological blood pressure. To investigate the bacterial and host factors, which contribute to this essential step of invasive meningococcal disease, the group of Alexandra Schubert-Unkmeir aims to develop an in vitro circulatory 2D N. meningitidis-endothelium interaction model. Work on this model and the impact of shear stress on N. gonorrhoeae-host interaction involves the groups of Vera Kozjak-Pavlovic and Thomas Rudel. Furthermore, a human in vitro 3D model of the blood-cerebrospinal fluid (B-CSF) barrier will be developed to study colonization and penetration of brain microvessels by N. meningitidis.