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Intern
    GRK 2243 "Understanding Ubiquitylation: From Molecular Mechanisms to Disease"

    Hermann Schindelin

    Prof. Dr. Hermann Schindelin

    Rudolf Virchow Center for Experimental Biomedicine
    University of Würzburg
    Josef-Schneider-Str. 2, D15
    D-97080 Würzburg

    Tel.: 0931 31-80382
    Fax.: 0931 31-87320

    Email: hermann.schindelin@virchow.uni-wuerzburg.de
    Web: www.virchow-zentrum.uni-wuerzburg.de


    Research Area:
    Structural Biology, Biochemistry

    Research in the Schindelin lab aims to decipher structure-function relationships for enzymes involved in the maturation as well as degradation of proteins and for proteins, which establish, modify and maintain inhibitory postsynaptic architectures.
    In the context of the research training group GRK 2243, the Schindelin lab investigates on the one hand the structure and function of selected E1 enzymes, which catalyze the initial steps in the activation of ubiquitin or ubiquitin-like proteins and transfers these protein modifiers onto cognate ubiquitin-conjugating enzymes. On the other hand, the AAA ATPase p97, which plays pivotal roles in various cellular pathways including the endoplasmic reticulum associated protein degradation pathway is extensively investigated. A common denominator of the studies within the GRK 2243 is the development of small molecule-based inhibitors, which will modulate the enzyme activity and thus exhibit therapeutic potential.

    Research projects: Project A1, Project D1, Project D2, Project D4