Structural Biology, Biochemistry
Research in the Schindelin lab aims to decipher structure-function relationships for enzymes involved in the maturation as well as degradation of proteins and for proteins, which establish, modify and maintain inhibitory postsynaptic architectures.
In the context of the research training group GRK 2243, the Schindelin lab investigates on the one hand the structure and function of selected E1 enzymes, which catalyze the initial steps in the activation of ubiquitin or ubiquitin-like proteins and transfers these protein modifiers onto cognate ubiquitin-conjugating enzymes. On the other hand, the AAA ATPase p97, which plays pivotal roles in various cellular pathways including the endoplasmic reticulum associated protein degradation pathway is extensively investigated. A common denominator of the studies within the GRK 2243 is the development of small molecule-based inhibitors, which will modulate the enzyme activity and thus exhibit therapeutic potential.