piwik-script

Intern
    GRK 2243 "Understanding Ubiquitylation: From Molecular Mechanisms to Disease"

    Projects

    The research program comprises 15 research projects in four research areas:

    Project A1:
    Structural and functional insights into E1-E2 recognition


    Project A2:
    Elucidating regulatory principles in the E2 enzyme family

    • Sonja Lorenz, Rudolf Virchow Center for Experimental Biomedicine

    Project A3:
    Regulation of the SCF(b-TrCP) ubiquitin ligase via ubiquitylation of its substrate adaptor

    • Nikita Popov, Comprehensive Cancer Center Mainfranken

    Project B1:
    Structural and functional analysis of the Fbw7-Usp28 complex

    • Caroline Kisker, Rudolf Virchow Center for Experimental Biomedicine
    • Nikita Popov, Comprehensive Cancer Center Mainfranken
    • Andreas Schlosser, Rudolf Virchow Center for Experimental Biomedicine

    Project B2:
    Unmasking E3 ligase-DUB pairs in colorectal cancer


    Project B3:
    Mechanism of substrate recognition by chlamydial DUBs


    Project B4:
    Function of chlamydial DUBs during infection

    Project C1:
    Role of USP28 in resolving transcription-replication conflicts


    Project C2:
    Stabilization of N-MYC and MYC by Aurora-A


    Project C3:
    Role of HUWE1-mediated degradation of MIZ-1 in transcriptional elongation


    Project C4:
    Control of SREBP stability and transcriptional activity by FBXW7

    • Almut Schulze, Biocenter
    • Nikita Popov, Comprehensive Cancer Center Mainfranken

    Project D1:
    Molecular characterization of the p97 segregase activity


    Project D2:
    Dynamics of p97-cofactor interactions under cellular stress conditions


    Project D3:
    Identification of p97 cofactors and substrates critically affected in neurodegenerative diseases


    Project D4:
    Development of cofactor-specific small molecule inhibitors for p97