Projects
The research program comprises 15 research projects in four research areas:
Project A1:
Structural and functional insights into E1-E2 recognition
- Hermann Schindelin, Rudolf Virchow Center for Experimental Biomedicine
Project A2:
Elucidating regulatory principles in the E2 enzyme family
- Sonja Lorenz, Rudolf Virchow Center for Experimental Biomedicine
Project A3:
Regulation of the SCF(b-TrCP) ubiquitin ligase via ubiquitylation of its substrate adaptor
- Nikita Popov, Comprehensive Cancer Center Mainfranken
Project B1:
Structural and functional analysis of the Fbw7-Usp28 complex
- Caroline Kisker, Rudolf Virchow Center for Experimental Biomedicine
- Nikita Popov, Comprehensive Cancer Center Mainfranken
- Andreas Schlosser, Rudolf Virchow Center for Experimental Biomedicine
Project B2:
Unmasking E3 ligase-DUB pairs in colorectal cancer
- Markus Diefenbacher, Biocenter
Project B3:
Mechanism of substrate recognition by chlamydial DUBs
- Caroline Kisker, Rudolf Virchow Center for Experimental Biomedicine
- Thomas Rudel, Biocenter
Project B4:
Function of chlamydial DUBs during infection
- Thomas Rudel, Biocenter
- Caroline Kisker, Rudolf Virchow Center for Experimental Biomedicine
Project C1:
Role of USP28 in resolving transcription-replication conflicts
- Markus Diefenbacher, Biocenter
- Martin Eilers, Biocenter
- Nikita Popov, Comprehensive Cancer Center Mainfranken
Project C2:
Stabilization of N-MYC and MYC by Aurora-A
- Martin Eilers, Biocenter
- Christoph Sotriffer, Institute of Pharmacy
Project C3:
Role of HUWE1-mediated degradation of MIZ-1 in transcriptional elongation
- Martin Eilers, Biocenter
- Sonja Lorenz, Rudolf Virchow Center for Experimental Biomedicine
Project C4:
Control of SREBP stability and transcriptional activity by FBXW7
- Almut Schulze, Biocenter
- Nikita Popov, Comprehensive Cancer Center Mainfranken
Project D1:
Molecular characterization of the p97 segregase activity
- Alexander Buchberger, Biocenter
- Hermann Schindelin, Rudolf Virchow Center for Experimental Biomedicine
Project D2:
Dynamics of p97-cofactor interactions under cellular stress conditions
- Hermann Schindelin, Rudolf Virchow Center for Experimental Biomedicine
- Andreas Schlosser, Rudolf Virchow Center for Experimental Biomedicine
- Alexander Buchberger, Biocenter
Project D3:
Identification of p97 cofactors and substrates critically affected in neurodegenerative diseases
- Alexander Buchberger, Biocenter
- Andreas Schlosser, Rudolf Virchow Center for Experimental Biomedicine
Project D4:
Development of cofactor-specific small molecule inhibitors for p97
- Christoph Sotriffer, Institute of Pharmacy
- Hermann Schindelin, Rudolf Virchow Center for Experimental Biomedicine
