piwik-script

Intern
    GRK 2243 "Understanding Ubiquitylation: From Molecular Mechanisms to Disease"

    Projects

    The research program comprises 15 research projects in four research areas:

    Project A1:
    Structural and functional insights into E1-E2 recognition

    • Hermann Schindelin, Rudolf-Virchow-Zentrum - Center for Integrative and Translational Bioimaging

    Project A2 (completed):
    Elucidating regulatory principles in the E2 enzyme family

    • Sonja Lorenz, Max-Planck-Institut für biophysikalische Chemie

    Project A3 (completed):
    Regulation of the SCF(b-TrCP) ubiquitin ligase via ubiquitylation of its substrate adaptor

    • Nikita Popov, Comprehensive Cancer Center Mainfranken

    Project A5:
    Elucidating conformational coupling in HECT-type ubiquitin ligases

    Project A6:
    Cross-regulation between eukaryotic E3 ligases and chlamydial infection

    Project B1:
    Structural and functional analysis of the Fbw7-Usp28 complex

    • Caroline Kisker, Rudolf-Virchow-Zentrum - Center for Integrative and Translational Bioimaging
    • Nikita Popov, Comprehensive Cancer Center Mainfranken
    • Andreas Schlosser, Rudolf-Virchow-Zentrum - Center for Integrative and Translational Bioimaging

    Project B2 (completed):
    Unmasking E3 ligase-DUB pairs in colorectal cancer

    Project B3 (completed)
    Mechanism of substrate recognition by chlamydial DUBs

    Project B4:
    Function of chlamydial DUBs during infection

    Project B5:
    Structure-based design and synthesis of antimicrobial DUB inhibitors

    Project B6:
    Ubiquitin-modifying enzymes of Simkania negevensis and their role in infection

    Project C1 (completed):
    Role of USP28 in resolving transcription-replication conflicts

    Project C2 (completed):
    Stabilization of N-MYC and MYC by Aurora-A

    Project C3:
    Role of HUWE1-mediated degradation of MIZ-1 in transcriptional elongation

    Project C4 (completed):
    Control of SREBP stability and transcriptional activity by FBXW7

    • Almut Schulze, Biocenter
    • Nikita Popov, Comprehensive Cancer Center Mainfranken

    Project C5:
    Role of RNA Polymerase II ubiquitylation in transcription

    Project C6:
    TRIM ubiquitin ligases in MYC-dependent signaling to the innate immune system

    Project D1 (completed):
    Molecular characterization of the p97 segregase activity

    Project D2 (completed):
    Dynamics of p97-cofactor interactions under cellular stress conditions

    • Hermann Schindelin, Rudolf-Virchow-Zentrum - Center for Integrative and Translational Bioimaging
    • Andreas Schlosser, Rudolf-Virchow-Zentrum - Center for Integrative and Translational Bioimaging
    • Alexander Buchberger, Biocenter

    Project D3:
    Identification of p97 cofactors and substrates critically affected in neurodegenerative diseases

    • Alexander Buchberger, Biocenter
    • Andreas Schlosser, Rudolf-Virchow-Zentrum - Center for Integrative and Translational Bioimaging

    Project D4:
    Development of cofactor-specific small molecule inhibitors for p97