piwik-script

Deutsch Intern
Rudolf Virchow Center for Experimental Biomedicine

About the Schindelin Group

“Form Follows Function”, a principle of 20th century architecture, summarizes the idea that the shape of a building should reflect its intended purpose. In structural biology the principle is generally inverted, knowledge of the three-dimensional structure of biological macromolecules provides important insights into their functions, i.e. “Function Follows Form”. This insight provides the rational for our research efforts in which we heavily rely on X-ray crystallography, a key technique for the high-resolution structure analysis of soluble as well as membrane proteins of virtually any size, in combination with biochemical, biophysical and cell-based experiments.

Protein Structure and Function

In our studies we focus on two different topics:

(1) Protein folding and maturation in the endoplasmic reticulum as well as the degradation of proteins via the ubiquitin-dependent protein degradation pathway.

(2) Neuronal signal transmission via inhibitory neurotransmitter receptors such as the glycine and GABA(A) receptors as well as anchoring and transport of these receptors.

For further information please visit the home page of the Schindelin lab.

Kasaragod V, Hausrat TJ, Schaefer N, Kuhn M, Christensen NR, Tessmer I, Maric HM, Lindegaard Madsen K, Sotriffer C, Villmann C, Kneussel M, Schindelin H. Elucidating the Molecular Basis for Inhibitory Neurotransmission Regulation by Artemisinins. Neuron 2019 Jan 28 doi:doi.org/10.1016/j.neuron.2019.01.001. [Epub ahead of print]


Wagner A, Le TA, Brennich M, Klein P, Bader N, Diehl E, Paszek D, Weickhmann AK, Dirdjaja N, Krauth-Siegel RL, Engels B, Opatz T, Schindelin H, Hellmich UA. Inhibitor-induced dimerization of an essential oxidoreductase from African Trypanosomes. Angew Chem Int Ed Engl. 2019 Jan 3. doi: 10.1002/anie.201810470. [Epub ahead of print]


Hines RM, Maric HM, Hines DJ, Modgil A, Panzanelli P, Nakamura Y, Nathanson AJ, Cross A, Deeb T, Brandon NJ, Davies P, Fritschy JM, Schindelin H, Moss SJ. Developmental seizures and mortality result from reducing GABAA receptor α2-subunit interaction with collybistin. Nat Commun. 2018 Aug 7;9(1):3130. doi: 10.1038/s41467-018-05481-1.


Misra M., Kuhn M., Löbel M., An H., Statsyuk A.V., Sotriffer C., Schindelin H. (2017). Dissecting the Specificity of Adenosyl Sulfamate Inhibitors Targeting the Ubiquitin-Activating Enzyme. Structure. 2017 Jul 5;25(7):1120-1129.e3. doi: 10.1016/j.str.2017.05.001. Epub 2017 Jun 1.


Kasaragod, V.B., Schindelin, H. (2016). Structural Framework for Metal Incorporation during Molybdenum Cofactor Biosynthesis. Structure. May 3;24(5):782-8. doi: 10.1016/j.str.2016.02.023. Epub Apr 21.


Hänzelmann, P.; Schindelin, H. (2016). Characterization of an Additional Binding Surface on the p97 N-Terminal Domain Involved in Bipartite Cofactor Interactions. Structure. 24(1): 140-7. doi: 10.1016/j.str.2015.10.026. Epub 2015 Dec 17.


Hänzelmann, P.; Schindelin, H. (2016). Structural Basis of ATP Hydrolysis and Intersubunit Signaling in the AAA+ ATPase p97. Structure. 24(1):127-39. doi: 10.1016/j.str.2015.10.026. Epub 2015 Dec 17.


Delto C.F., Heisler F.F., Kuper J., Sander B., Kneussel M., Schindelin H. (2015). The LisH motif of muskelin is crucial for oligomerization and governs intracellular localization. Structure. 2015 Feb 3;23(2):364-73. doi: 10.1016/j.str.2014.11.016. Epub 2015 Jan 8.


Maric H.M., Kasaragod V.B., Hausrat T.J., Kneussel M., Tretter V., Strømgaard K., Schindelin H. (2014). Molecular basis of the alternative recruitment of GABA(A) versus glycine receptors through gephyrin. Nat Commun. 2014 Dec 22;5:5767. doi: 10.1038/ncomms6767.


Maric H.M., Kasaragod V.B., Haugaard-Kedström L., Hausrat T.J., Kneussel M., Schindelin H., Strømgaard K. (2015). Design and synthesis of high-affinity dimeric inhibitors targeting the interactions between gephyrin and inhibitory neurotransmitter receptors. Angew Chem Int Ed Engl. 2015 Jan 7;54(2):490-4. doi: 10.1002/anie.201409043. Epub 2014 Nov 20.


Soykan T., Schneeberger D., Tria G., Buechner C., Bader N., Svergun D., Tessmer I, Poulopoulos A, Papadopoulos T, Varoqueaux F, Schindelin H, Brose N. (2014). A conformational switch in collybistin determines the differentiation of inhibitory postsynapses. EMBO J. 2014 Sep 17;33(18):2113-33. doi: 10.15252/embj.201488143. Epub 2014 Jul 30.


Grimm C., Chari A., Pelz J.P., Kuper J., Kisker C., Diederichs K., Stark H., Schindelin H., Fischer U. (2013). Structural basis of assembly chaperone- mediated snRNP formation. Mol Cell. 2013 Feb 21;49(4):692-703. doi: 10.1016/j.molcel.2012.12.009. Epub 2013 Jan 17.


Maric H.M., Mukherjee J., Tretter V., Moss S.J., Schindelin H. (2011). Gephyrin-mediated γ-aminobutyric acid type A and glycine receptor clustering relies on a common binding site. J Biol Chem. 2011 Dec 9;286(49):42105-14. doi: 10.1074/jbc.M111.303412. Epub 2011 Oct 17.


Hänzelmann P., Schindelin H. (2011). The structural and functional basis of the p97/valosin-containing protein (VCP)-interacting motif (VIM): mutually exclusive binding of cofactors to the N-terminal domain of p97. J Biol Chem. 2011 Nov 4;286(44):38679-90. doi: 10.1074/jbc.M111.274506. Epub 2011 Sep 13.


Hänzelmann P., Buchberger A., Schindelin H. (2011). Hierarchical binding of cofactors to the AAA ATPase p97. Structure. 2011 Jun 8;19(6):833-43. doi: 10.1016/j.str.2011.03.018.


Lee I., Schindelin H. (2008). Structural insights into E1-catalyzed ubiquitin activation and transfer to conjugating enzymes. Cell. 2008 Jul 25;134(2):268-78. doi: 10.1016/j.cell.2008.05.046.


Kim E.Y., Schrader N., Smolinsky B., Bedet C., Vannier C., Schwarz G., Schindelin H. Deciphering the structural framework of glycine receptor anchoring by gephyrin. EMBO J. 2006 Mar 22;25(6):1385-95. Epub 2006 Mar 2.


Tian G., Xiang S., Noiva R., Lennarz W.J., Schindelin H. (2006). The crystal structure of yeast protein disulfide isomerase suggests cooperativity between its active sites. Cell. 2006 Jan 13;124(1):61-73. Erratum in: Cell. 2006 Mar 10;124(5):1085-8.


Hänzelmann P., Schindelin H. (2004). Crystal structure of the S-adenosylmethionine-dependent enzyme MoaA and its implications for molybdenum cofactor deficiency in humans. Proc Natl Acad Sci U S A. 2004 Aug 31;101(35):12870-5. Epub 2004 Aug 18.


Lake M.W., Leimkühler S., Wuebbens M.M., Rajagopalan K.V., H. Schindelin. (2001). “The crystal structure of the MoeB-MoaD complex provides insights into the mechanism of ubiquitin activation”, Nature 414, 325-329.


Rudolph M.J., Wuebbens M.M., Rajagopalan K.V., Schindelin H. (2001). Crystal structure of molybdopterin synthase and its evolutionary relationship to ubiquitin-activation. Nature Struct. Biol. 8, 42-46. 

Nicole Bader

Technische/r Assistent/in
Rudolf-Virchow-Zentrum für Experimentelle Biomedizin
Universität Würzburg
Josef-Schneider-Str. 2
97080Würzburg
Deutschland
Building: Haus D15
Room: 00.018

Teresa Frank

Mitarbeiter/in Verwaltung - Sekretariat
Rudolf-Virchow-Zentrum für Experimentelle Biomedizin
Universität Würzburg
Josef-Schneider-Str. 2
97080Würzburg
Deutschland
Building: Haus D15
Room: 00.040

Carolina Galgenmüller

Doktorand/in
Rudolf-Virchow-Zentrum für Experimentelle Biomedizin
Universität Würzburg
Josef-Schneider-Str. 2
97080Würzburg
Deutschland
Building: Haus D15
Room: 00.018

Dr. Petra Hänzelmann

Postdoc
Rudolf-Virchow-Zentrum für Experimentelle Biomedizin
Universität Würzburg
Josef-Schneider-Str. 2
97080Würzburg
Deutschland
Building: Haus D15
Room: 00.020

Nasir Imam

Doktorand/in
Rudolf-Virchow-Zentrum für Experimentelle Biomedizin
Universität Würzburg
Josef-Schneider-Str. 2
97080Würzburg
Deutschland
Building: Haus D15
Room: 00.017

Dr. Vikram Kasaragod

Postdoc
Rudolf-Virchow-Zentrum für Experimentelle Biomedizin
Universität Würzburg
Josef-Schneider-Str. 2
97080Würzburg
Deutschland
Building: Haus D15
Room: 00.017

Monika Kuhn

Technische/r Assistent/in
Rudolf-Virchow-Zentrum für Experimentelle Biomedizin
Universität Würzburg
Josef-Schneider-Str. 2
97080Würzburg
Deutschland
Building: Haus D15
Room: 00.022

Anabel Pacios Michelena

Doktorand/in
Rudolf-Virchow-Zentrum für Experimentelle Biomedizin
Universität Würzburg
Josef-Schneider-Str. 2
97080Würzburg
Deutschland
Building: Haus D15
Room: 00.021

Aparna Pottikkadavath

Doktorandin
Rudolf-Virchow-Zentrum für Experimentelle Biomedizin
Universität Würzburg
Josef-Schneider-Str. 2
97080Würzburg
Deutschland
Building: Haus D15
Room: 00.021

Prof. Dr. Hermann Schindelin

Gruppenleiter
Rudolf-Virchow-Zentrum für Experimentelle Biomedizin
Universität Würzburg
Josef-Schneider-Str.2
97080Würzburg
Deutschland
Building: Haus D15
Room: 00.023

Andrea Schott-Heinzmann

Sekretariat
Rudolf-Virchow-Zentrum für Experimentelle Biomedizin
Universität Würzburg
Josef-Schneider-Str. 2
97080Würzburg
Deutschland
Building: Haus D15
Room: 00.016

Dr. Andrea Thorn

Rudolf-Virchow-Zentrum für Experimentelle Biomedizin
Universität Würzburg
Josef-Schneider-Str. 2
97080Würzburg
Deutschland
Building: Haus D15
Room: 00.042

Ngoc Truongvan

Doktorand
Rudolf-Virchow-Zentrum für Experimentelle Biomedizin
Universität Würzburg
Josef-Schneider-Str. 2
97080Würzburg
Deutschland
Building: Haus D15
Room: 00.017

Current position

Professor of Structural Biology and Biochemistry at the Rudolf Virchow Center of  University of Würzburg (since 2006)

Research Experience

2002-2006   Associate Professor, Stony Brook University, USA
1998-2002   Assistant Professor, Stony Brook University, USA
1994-1998   Postdoc, California Institute of Technology, Pasadena, CA, USA

Education

1991-1994    Dr. rer. nat (PhD) Biochemistry and Structural Biology, Freie Universität Berlin, Germany

Awards and Fellowships

  • Graduate Fellowship Deutsche Forschungsgemeinschaft (1991-1994)
  • Postdoctoral Fellowship from the Deutsche Forschungsgemeinschaft (1995-1997)
  • Postdoctoral Fellowship from the Howard Hughes Medical Institute (1997-1998)
  • Targeted Research Opportunity Award, Stony Brook University (2001-2003)

Selected professional activities

  • Member of Participating Research Team of Beam Line X26C at the National Synchrotron Light Source at Brookhaven National Laboratory (1998-2006)
  • Spokesperson for the Participating Research Team of Beam Line X26C at the National Synchrotron Light Source at Brookhaven National Laboratory (2004-2006)
  • Member of the Admissions Committee for the Graduate Program in Molecular and Cellular Biology (2000-2001)
  • Director of Admissions for Graduate Program in Biochemistry and Structural Biology (2000-2006) 
  • Member of the Molecular and Cellular Biology Graduate Program Executive Committee (2000-2006)
  • Speaker of the section Molecular Biosciences within the Graduate School of Life Sciences at the Uni Würzburg (since 2014)
  • Speaker Interest Group 1 “Biological Crstallography” of the German Society for Crystallography (since 2014)
  • Coopted member of the “Committee on Research with Synchrotron Radiation” (since 2015)
  • Member of the Editorial Board of the Journal of Biological Chemistry (since 2015)

Position

Professor for Biochemistry/Structural Biology - Rudolf Virchow Center
Member - Graduate School of Life Sciences
Supervisor and Member in different thesis committees - Graduate School of Life Sciences/Biomedicine

Courses

  • Structures and functions of biological makromolecules (for Bachelorstudents)
  • Macromolecular crystallography (for Masterstudents)
  • Journal Club: Ubiquitin proteasome system (for Masterstudents and PhD students)
  • Journal Club: Ion channels and associated proteins(for Masterstudents and PhD students)
  • Study related work in a research lab (for Bachelor- and Masterstudents)

Further information about courses in winter/summer term can be found here.