GRK 2243 "Understanding Ubiquitylation: From Molecular Mechanisms to Disease"

Alexander Buchberger (spokesperson)

Prof. Dr. Alexander Buchberger

Department of Biochemistry
Biocenter, University of Würzburg
Am Hubland
D-97074 Würzburg

Tel.: 0931 31-88031
Fax.: 0931 31-84028


Research Area:
Biochemistry, Molecular Cell Biology

The Buchberger lab studies the regulated intracellular degradation of proteins by the ubiquitin-proteasome system. The focus of our research is on the ubiquitin-selective, chaperone-related ATPase Cdc48/p97. We use biochemical, cellular, and structural approaches to investigate mechanisms underlying target protein recognition and turnover. Our aim is to understand the pathological consequences of defective protein degradation in neurodegenerative diseases and cancer.

Research projects: Project D1, Project D2, Project D3