GRK 2243 "Understanding Ubiquitylation: From Molecular Mechanisms to Disease"

    Christoph Sotriffer

    Prof. Dr. Christoph Sotriffer

    Institute of Pharmacy and Food Chemistry
    University of Würzburg
    Am Hubland
    D-97074 Würzburg

    Tel.: 0931 31-85443
    Fax.: 0931 31-85494

    Email: sotriffer@uni-wuerzburg.de
    Web: www.pharmazie.uni-wuerzburg.de

    Research Area:
    Computer-aided drug design

    The Sotriffer lab is dedicated to computational medicinal chemistry and computer-aided molecular design. In particular, we are interested in the investigation of protein-ligand interactions and computational methods for structure-based drug design. We develop new scoring functions for the prediction of binding affinities and apply virtual screening and docking techniques to develop new ligands for protein targets of known structure. To improve our understanding of the properties of particular protein-ligand complexes, we make extensive use of molecular dynamics simulations. All this work is generally embedded in tight collaborations, in particular with structural biologists and medicinal chemists.

    Research projects: Project C2, Project D4