Researchers at the University of Würzburg develop the "photoswitching fingerprint analysis". A unique technology that for the first time allows the analysis of molecular processes and the regulation of individual proteins in living cells with sub-10 nm spatial resolution. The application ranges from biological to medical research and has been published in the renowned journal Nature Methods.

Inhibitory synapses in neuron cultures and brain tissue can now be visualized with ease and with high contrast. The newly developed synthetic affinity probe Sylite can be applied both for widefield and confocal 3D volumetric synapse visualization, for in-tissue inhibitory circuits mapping and for super-resolution imaging of synapses.

Cerebral venous thrombosis is a rare, often severe disease that has been brought to public attention by the Covid 19 pandemic. A research group from Würzburg has now succeeded for the first time in deciphering a molecular cause of this disease. This opens the way to new therapeutic approaches. Published in Nature Cardiovascular Research.