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    Rudolf Virchow Center for Integrative and Translational Bioimaging

    Touchable corona viruses

    07/31/2020

    Würzburg research group prints the first biologically correct 3D model of the SARS-CoV-2 virus

    Figure 1: The 3D printed model of the SARS-CoV-2 corona virus and an antibody in the scale 1 : 1,000,000.

    Viruses are tiny. They cannot be seen with the naked eye and they are even too small for optical microscopes, which makes it difficult to recognize the danger that COVID-19 and its pathogen SARS-CoV-2 pose to the world. This is why the international Coronavirus Structural Task Force led by Dr. Andrea Thorn from the Rudolf Virchow Center of the University of Würzburg has now developed a 3D model of the novel coronavirus which can even be touched. The model measures 17 cm in diameter and can be printed with a normal 3D printer. The scientists study the molecules which make up the coronavirus and analyse it atom by atom. These findings went into the new model.

    International team bundles expertise

    23 researchers from seven different countries and different fields such as chemistry, physics, computer science and structural biology are working closely together to gain new insights into the inner workings of the virus. They analyse every new molecular structure which is published, over 500 so far. Their make their improved molecular structures along with additional data available for drug developers worldwide in order to accelerate the development of a therapy or vaccines.

    Making the state of knowledge accessible

    What is remarkable about this model is its scientific accuracy: it realistically depicts the relative sizes and structures of the virus on a 1 : 1,000,000 scale. The virus hull carries not only the spike proteins (painted green in the photo) but two more types of protein molecules (lighter green and yellow). As opposed to common depictions, the coronavirus is not exactly round or symmetrical, but can vary in shape and size. Instructions for 3D printing and painting the virus model along with the necessary files are available at the Corona Structural Task Force homepage https://insidecorona.net/what-does-the-coronavirus-really-look-like/. Interested parties can also find a state-of-the-art depiction of the viral infection cycle, as well as blog posts and information about the molecules of the virus on the homepage. „We hope that this will make the virus more tangible“ says Thorn, hoping that the model will give children and adults alike an insight into the structural biology of the coronavirus.

    About the Rudolf Virchow Center
    The Rudolf Virchow Center is a central institution of the University of Würzburg. The research groups are working on key proteins are essential for cellular function and therefore central to health and disease.

    Contact
    Dr. Andrea Thorn (Rudolf Virchow Center, University of Würzburg, Germany)
    Tel. 0931 31 83677, andrea.thorn@virchow.uni-wuerzburg.de

    Dr Judith Flurer (Press Office, Rudolf Virchow Center, Germany)
    Tel. 0931 31 85822, judith.flurer@virchow.uni-wuerzburg.de

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