The following positions are currently available at the Rudolf Virchow Center:
The Thorn Laboratory at the University of Würzburg (Germany) is recruiting a
PhD candidate (m/f/d) in crystallographic methods development
Macromolecular X-ray structures define molecular biology. However, the large discrepancy between the measured X-ray data and the structural models we use to interpret these data (as evidenced by R-values of 15-25%) clearly shows that something is amiss. This project aims to discover what is missing through statistical analyses of practical experiments. This knowledge will then be used to improve how structures of biological macromolecules are modeled and ultimately, to enable structural biologists to answer more challenging biological questions.
What we offer
We offer a 36-month full- or part-time position at the Rudolf-Virchow Center of the University Wuerzburg, with a competitive TV-L salary, funded as part of the DFG project “Towards a better understanding of macromolecular X-ray structures”. This rewarding and challenging research project will allow you to acquire skills in applied structural biology and its theoretical foundations as well as data analysis including programming and machine learning. You will have access to state-of-the-art equipment and our group is well-connected; you will have the opportunity to visit several international collaboration partners. Through the Graduate School for Life Sciences you will have a personal thesis committee to guide you and benefit from their extensive transferable skill program. You will get access to national and public-service pension schemes (VBL), health care, and 30 days of holiday. The JMU Welcome Center supports international candidates with language classes and practical advice - and the University also offers support for researchers with children.
Your qualification profile
You should have a M.Sc. or equivalent in a relevant subject or be due to complete your studies within 2 months of applying. We are looking for someone with a good working knowledge of Linux and Python and a basic understanding of crystallography. Skills in statistical or image analysis, C++ and previous experience with machine learning are a bonus. You should be able to develop your own ideas, and have the necessary skills to successfully drive and complete a research project. You should be a good communicator and a good command of English is a prerequisite. You will be expected to present your work both at in-house and international meetings, and to contribute on occasion to teaching and public outreach. Female scientists are particularly encouraged to apply. Disabled applicants will be preferentially considered in case of equivalent qualification.
Applications should be sent by e-mail (until 26th July 2020) as one single pdf-document including: cover letter (stating why you are interested in this position specifically), curriculum vitae (detailing any data analysis, programming and crystallographic qualifications), diplomas/certificates and three addresses of referees to firstname.lastname@example.org.
If you have any further questions, please do not hesitate to contact us!
PhD Position (f/m/d) investigating the
“The role of eukaryotic deubiquitinases in disease” is available in the group of Prof. Dr. Kisker
Ubiquitination is one of the most important posttranslational modifications as it is involved in the regulation of multiple highly divergent cellular processes. This modification can be reversed by deubiquitinases, which can remove single or multiple ubiquitin molecules from their targets. The Kisker lab is interested in the regulation and specificity of deubiquitinases in essential cellular processes and disease (see for example: Sauer, Klemm et al., Mol Cell 2019, Ramirez et al., ChemMedChem 2018).
Highly motivated candidates with a Masters (or equivalent) degree in biochemistry, molecular biology, biophysics or chemistry and a keen interest in structural biology, biochemistry, and biophysics are strongly encouraged to apply (starting date 15th June 2020). Successful applicants must be able to work independently and as part of an international team. Previous experience in one of the following areas, structural biology, biochemistry or biophysics, is required.
Interested candidates should E-mail an application including a cover letter detailing their interests and expertise, their CV, transcripts, and the contact information of at least two references. The position will be financed via the GRK 2243 "Understanding Ubiquitylation: From Molecular Mechanisms to Disease". The successful applicant will have the opportunity to enroll in the Graduate School of Life Sciences in Würzburg – an international graduate program. Salary will be according to the collective bargaining agreement (TV-L, 65%). Disabled applicants will be preferentially considered in case of equivalent qualifications.
For further information and to apply please contact:
Prof. Dr. Caroline Kisker
Rudolf-Virchow-Zentrum für Experimentelle Biomedizin Universität Würzburg
Josef-Schneider-St. 2 / Haus D15
Please submit your application as a single pdf file by mail until 1st June 2020 .