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Rudolf Virchow Center for Experimental Biomedicine

Job Offers

The following positions are currently available at the Rudolf Virchow Center:

Science

The Thorn Laboratory at the Rudolf Virchow Center of the University of Würzburg (Germany) is recruiting a

PhD candidate (m/f/d)
In crystallographic methods development

Macromolecular X-ray structures define molecular biology. However, the large discrepancy between the measured X-ray data and the structural models we use to interpret these data (as evidenced by residual values of 15-25%) clearly shows that something is amiss. This project aims to discover what is missing, using both practical experiments and ‘big data’ analyses (including machine learning). This knowledge will then be used to fundamentally improve how atomic structures of biological macromolecules are modeled and ultimately, enable structural biologists solve more borderline cases, extract more information from known biological structures, and to answer more challenging biological questions.

What we offer

We offer a 36-month 65% (full- or part-time) position at the Rudolf-Virchow Center (RVZ) of the University Würzburg, with a competitive TV-L salary, funded as part of the DFG project “Towards a better understanding of macromolecular X-ray structures”.

This rewarding and challenging research project will allow you to acquire skills in applied structural biology and its theoretical foundations as well as data analysis including programming and machine learning. You will have access to state-of-the-art equipment and our group is well-connected; you will have the opportunity to visit several international collaboration partners. Through the Graduate School for Life Sciences you will have a personal thesis committee to guide you and benefit from their extensive transferable skill program.

You will have access to both national and public-service pension schemes (VBL), health care, and 30 days of holiday entitlement in addition to 13 annual public holidays in Bavaria. The JMU Welcome Center supports international candidates in finding accommodation as well as administrative matters - and the University also offers support for researchers with children.

Your qualification profile

You should have a M.Sc. or equivalent in a relevant subject or be due to complete your studies within 2 months of applying. We are looking for someone with a good working knowledge of Linux and Python and a basic understanding of crystallography (irrespective of the field, e.g. mineralogy, structural physics, biology or chemistry). Skills in statistical or image analysis, C++ and previous experience with machine learning are a bonus. You should be able to develop your own ideas, and have the necessary skills to successfully drive and complete a research project. You should be a good communicator and a good command of English is a prerequisite. You will be expected to present your work both at in-house and international meetings, and to contribute on occasion to teaching and public outreach.

Female scientists are particularly encouraged to apply. Disabled applicants will be preferentially considered in case of equivalent qualification.

Applications should be sent by e-mail as one single pdf-document including: cover letter (stating why you are interested in this position specifically), curriculum vitae (detailing any data analysis, programming and crystallographic qualifications), diplomas/certificates and three addresses of referees by January 31st, 2020 to andrea.thorn@uni-wuerzburg.de.

If you have any further questions, please do not hesitate to contact us.

Rudolf-Virchow-Zentrum für Experimentelle Biomedizin
Universität Würzburg
Dr. Andrea Thorn
Josef-Schneider-Str. 2 / Haus D15
D-97080 Würzburg

Thorn lab page:
https://www.uni-wuerzburg.de/rvz/forschung/assoziierte-forschungsgruppen/ag-thorn/

 

 

The Thorn Laboratory at the University of Würzburg (Germany) is recruiting a

Postdoctoral Researcher (m/f/d)
in crystallographic methods development 

Structures of biomolecules, such as the DNA double helix or protein drug targets, are usually solved with single-crystal diffraction. However, these data are often flawed. We  are looking to recruit a researcher to find the problems in the experiment and the subsequent data processing with our collaboration partners at BESSY and ESRF synchrotrons, the European Spallation Source as well as the European XFEL. You will then develop new automatic and visual diagnostics for these problems and diffraction experiments in general, employing statistical data analysis as well as machine learning. This will ultimately enable us to improve measurements and processing of diffraction data as well as to define new best practices for macromolecular diffraction experiments.

What we offer

We offer a 30-month full- or part-time position at the Rudolf-Virchow Center (RVZ) of the University Würzburg, the birthplace of X-rays, with a competitive TVL salary; your position is funded by the German Federal Ministry of Education and Research (BMBF) as part of the AUSPEX project. AUSPEX is part of the CCP4 suite for macromolecular crystallography. This exciting project will allow you to define new standards in macromolecular structure determination and to establish a network in the crystallographic community; your findings will be implemented in software and published in peer-reviewed journals.

At the RVZ, a range of training and development opportunities will be available to you, including career support. You will have access to health care and both national and public-service pension schemes. The Welcome Center supports international candidates and the University also offers support for researchers with children, including flexible work hours and a kindergarten.

Your qualification profile

You should have a doctoral degree in structural biology, physics or other relevant subject or be due to complete your doctoral studies within 3 months of applying. You should have the necessary skills to successfully drive and complete a research project, both working independently and as part of a team. We are looking for someone with a good working knowledge of Linux, Python and C++. You should be good at data analysis and already have basic experience with crystallography. Female scientists are particularly encouraged to apply. Disabled applicants will be preferentially considered in case of equivalent qualification.

Female scientists are particularly encouraged to apply. Disabled applicants will be preferentially considered in case of equivalent qualification.

Applications should be sent by e-mail as one single pdf-document including: cover letter (stating why you are interested in this position specifically), curriculum vitae (detailing any software and crystallographic skills), diplomas/certificates and three addresses of referees by January 31st, 2020 to  andrea.thorn@uni-wuerzburg.de.

If you have any further questions, please do not hesitate to contact us!

Rudolf-Virchow-Zentrum
Universität Würzburg
Dr. Andrea Thorn
Josef-Schneider-Str. 2 / Haus D15
D-97080 Würzburg

Thorn lab page // Latest  press release

Why do your postdoc in Germany?