The following positions are currently available at the Rudolf Virchow Center:
PhD Position (f/m/d) investigating the
“Structural and biochemical characterization of protein ubiquitylation” is available in the group of Prof. Dr. Schindelin
The covalent modification of target proteins with ubiquitin serves a variety of important cellular responses. In humans ubiquitin is attached to target proteins via a hierarchical cascade of two ubiquitin activating enzymes (E1), dozens of ubiquitin conjugating enzymes (E2) and several hundred ubiquitin ligases (E3). The Schindelin lab is interested in various enzymes involved in this cascade (see for example: Lee and Schindelin, Cell 134, 268-278 (2008); Misra et al., Structure 25, 1120-1129, 2017, Hänzelmann and Schindelin, Structure 24, 127-139 and 140-147, 2016).
Highly motivated candidates with a Masters (or equivalent) degree in biochemistry, molecular biology, biophysics or chemistry and a keen interest in structural biology, biochemistry, and biophysics are strongly encouraged to apply (starting date 1st December 2020 or January 2021). Successful applicants must be able to work independently and as part of an international team. Previous experience in one of the following areas, structural biology, biochemistry or biophysics, is required.
Interested candidates should E-mail an application including a cover letter detailing their interests and expertise, their CV, transcripts, and the contact information of at least two references. The position will be financed via the GRK 2243 “Understanding Ubiquitylation: From Molecular Mechanisms to Disease” and the PhD student will be part of the Graduate School of Life Sciences. Salary will be according to the collective bargaining agreement (TV-L, 65%). Disabled applicants will be preferentially considered in case of equivalent qualifications.
For further information and to apply please contact:
Prof. Dr. Hermann Schindelin
Rudolf-Virchow-Zentrum - Center for Integrative and Translational Bioimaging der Universität Würzburg
Josef-Schneider-St. 2 / Haus D15
Lab Homepage: http://virchow-zentrum.uni-wuerzburg.de/lab_pages/schindelin/
Please submit your application as a single pdf file by mail to email@example.com until 15th November 2020.
The Rudolf Virchow Center - Center for Integrative and Translational Bioimaging and the University Hospital of Würzburg, Department of Neurology, offer a position as
PhD student (f/m/d)
Identification of new immune neuropathy autoantigens
We are looking for a highly motivated PhD student for cross-disciplinary research within the Doppler and Maric groups with the goal to identify and characterize new immune neuropathy autoantigens. The project will encompass the use of synthetic chemistry, biophysical characterisation of biomolecular binding interactions and modern automatization technologies to unravel the molecular pathogenesis of nodal and paranodal autoantibodies and thereby improve diagnosis and, consecutively, the therapy of patients with autoimmune neuropathies.
Project: In autoimmune neuropathies, nerve fibre damage leads to paresis, sensory deficits and autonomic dysfunction often resulting in severe physical disability of the patient. A subgroup of autoimmune neuropathies is caused by autoantibodies against critical nerve structures. Here, disease severity correlates with antibody levels and antibody neutralisation or removal can achieve immediate patient recovery. So far, however, only a minor fraction of the existing autoantigens could be identified. To address this major limitation in diagnostic and therapeutic options we aim to discover new autoantigens at critical structures of the peripheral nerves. The identification of new autoantigens and their exact binding epitopes will help to unravel the molecular pathogenesis of nodal and paranodal autoantibodies, monitor epitope-spreading during the course of disease and explore autoantibody neutralisation.
Requirements: You possess a Master-degree or similar related to life sciences, chemistry or biomedicine and a strong background in Biochemistry. Experiences and knowledge related to protein and peptide chemistry, biophysical protein/antibody characterisation, Neurobiology, Bioimaging or Immunology are beneficial. You have good English skills and you like to work and interact across disciplines. To change the status-quo and help to create new breakthroughs you prefer to perform in networks.
Our offer: The successful candidate will work within the Doppler and Maric groups. We provide excellent technical equipment and the possibility to further develop and apply biomedical technologies related to the identification and characterisation of antibodies directly from patient samples. The Programme is a joint effort of the Department of Neurology of the University Hospital Würzburg and the Rudolf Virchow Center and funded by the interdisciplinary center of clinical research (IZKF). Hence, a stimulating collaborative research environment with multiple excellent research groups is provided. The promotion will be conducted within the structured framework of the Graduate School of Life Sciences of the University of Würzburg. Disabled applicants will be preferentially considered in case of equivalent qualifications. The three years position can start immediately or upon mutual agreement. The salary for this temporary position is commensurate with training and experience according to the Collective Agreement for the Public Service of German Federal States TV-L.
Application: Single page cover letter describing previous research experience, interests and motivation. Single page CV with education and contact details of two references and a list of publications. Please submit the two pages application as a single pdf file (no more than 10 MB) via email to Hans.Maric@virchow.uni-wuerzburg.de, subject: “Autoantigens”, until 23rd of November. Review of applications will begin immediately.
PD Dr. Kathrin Doppler Dr. Hans Maric
Department of Neurology Rudolf Virchow Center
University Hospital Würzburg University of Würzburg
Josef-Schneider-Str. 2, Haus D15