The Rudolf Virchow Center for Integrative and Translational Bioimaging (RVZ) is a multidisciplinary research institute of the University of Würzburg, Germany. RVZ scientists perform innovative basic and translational research with a focus on state-of-the-art imaging technologies. The group of Dr. José Pedro Friedmann Angeli invites applications for
1 PhD Position (f/m/d) in Cell Death and Cancer Metabolism
Our main goal is to understand the process that allow cells to cope and adapt to oxidative stress with a particular focus on a cell death modality known as ferroptosis. Ferroptosis has amassed increased attention as a strategy to kill tumor entities and states that challenge current treatments strategies. In our group we aim to explore and identify basic mechanism regulating ferroptosis and leverage them in the context of selected malignancies such as adrenocortical carcinomas and multiple myeloma.
Job description: The successful candidate will investigate the cellular and molecular mechanisms of ferroptosis and explore pharmacological and antibody based strategies to inhibit this pathways in relevant settings. For this, the applicant will apply functional genetics methodologies such as CRISPR/Cas9 screen and additional methods including RNA sequencing, tumor mouse model (genetic and xenografts), metabolomics and protein biochemistry.
The position is available immediately or upon mutual agreement for 3 years initially. The salary will be according to the collective bargaining agreement (TV-L, 65%). Disabled applicants will be preferentially considered in case of equivalent qualifications.
Please submit your application, including a single page motivation letter (stating your soonest availability for the position), your CV, list of publications and contact details of two referees as single PDF (less than10 MB) to Dr. José Pedro Friedmann Angeli firstname.lastname@example.org. The position will remain open until it is filled.
Rudolf-Virchow-Zentrum – Center for Integrative and Translational Bioimaging
Dr. José Pedro Friedmann Angeli
Josef-Schneider-Str. 2/Haus D15
The University and University Hospital of Würzburg are well-renowned centers for research and clinical studies in cancer therapy and are strongly linked to the Comprehensive Cancer Center funded by the German Cancer Aid.
For advancing new experimental therapy approaches for tumor treatment, we are looking for a highly motivated PhD student for a translational project funded by the German Cancer Aid.
The project “Exploiting nucleotide excision DNA repair as drug target in cancer therapy” is part of a collaborative project aiming at establishing the nucleotide excision repair helicase XPD as drug target for sensitizing melanomas to standard therapy. The experimental focus will be molecular biology and biochemistry of cell culture and animal models, and there will be close interactions with the Department of Structural Biology.
The PhD position will be associated with the laboratories of Prof. Dr. Svenja Meierjohann (Institute of Pathology) and Prof. Dr. Bastian Schilling (Department of Dermatology, Allergology and Venereology).
- Salary according to the collective bargaining agreement (TV-L, 65%, 3 years, PhD student)
- Intellectual support and supervision
- Enrollment into the Graduate School for Life Sciences
- Professional skills training
- Close collaborations with the Departments of Pathology, Dermatology and Structural Biology
- an international, collaborative and family friendly working environmen
- childcare facilities
APPLY IF YOU HAVE
- High motivation and a keen interest in tumor biochemistry and translational oncology
- masters (or equivalent) degree in biochemistry, (molecular) biology or similar
To apply, please electronically submit your CV, two recommendation letters and a one-page letter of motivation. The University of Würzburg and the University Hospital Würzburg are equal opportunities employers. Women and persons with disabilities are encouraged to apply. Applications of people with special needs are particularly welcome. The project will start after the position has been occupied.
Prof. Dr. Svenja Meierjohann
Tumor biochemistry group
University of Würzburg
Institute of Pathology
Josef-Schneider Str. 2
Prof. Dr. Bastian Schilling
Department of Dermatology, Venereology and Allergology
University Hospital Würzburg