Deutsch Intern
    Graduiertenkolleg 2581

    Project 2

    Measles virus dependent regulation of sphingolipids at the T cell plasma membrane and their differential role in effector and memory T cell function

    Elita Avota,  Markus Sauer

    The role of measles virus (MV)-induced and sphingomyelinase dependent modulation of lipids and lipid-regulated protein topology, functionality at the plasma membrane of T cells as the part of suppression of immune responses.

    The project includes:

    1) sphingomyelinase activity and lipid profile analysis of the different T cell subsets treated with MV upon hypoxic and high density cell culture conditions mimicking the environment within secondary lymphatic tissue;

    2) plasma membrane protein and lipid visulaization by super-resolution microscopy techniques (dSTORM, SIM) including usage of functionalized synthetic sphingolipids.


    PhD topic: Super-resolution microscopy of sphingolipids at the T cell plasma membrane during measles virus infection


    Elita Avota

    Markus Sauer