Deutsch Intern
  • SPHINGOINF
Graduiertenkolleg 2581

Publications

The sphingolipid inhibitor myriocin increases Candida auris susceptibility to amphotericin B

 

 The sphingolipid inhibitor myriocin increases Candida auris susceptibility to amphotericin B

H. Stieber, L. Junghanns, H. Wilhelm, M. Batliner, A. M. Aldejohann, O. Kurzai, R. Martin

Mycoses, 2024

first published: 29 March 2024

The Candida albicans quorum-sensing molecule farnesol alters sphingolipid metabolism in human monocyte-derived dendritic cells

The Candida albicans quorum-sensing molecule farnesol alters sphingolipid metabolism in human monocyte-derived dendritic cells

M. Batliner,  F. Schumacher, D. Wigger, W. Vivas, A. Prell,  I. Fohmann, T. Köhler, R. Schempp, A. Riedel,  M. Vaeth, A. Fekete, B. Kleuser, O. Kurzai, N. E. Nieuwenhuizen

MBio, 2024

first published: 2. July 2024

Caveolin-1 affects early mycobacterial infection and apoptosis in macrophages and mice

Caveolin-1 affects early mycobacterial infection and apoptosis in macrophages and mice

Y. Wu, A. Riehle, B. Pollmeier, S. Kadow, F. Schumacher, M. Drab, B. Kleuser, E. Gulbins, H. Grassmé

Tuberculosis, 2024

first published: 12 February 2024

Same yet different — how lymph node heterogeneity affects immune responses

Same yet different — how lymph node heterogeneity affects immune responses

P. Cruz de Casas , K. Knöpper , R. Dey Sarkar and W. Kastenmüller 

Nat. Rev. Immunol.2023

first published: 14 December 2023

Sphingosine kinase 1/S1P receptor signaling axis is essential for cellular uptake of Neisseria meningitidis in brain endothelial cells

Sphingosine kinase 1/S1P receptor signaling axis is essential for cellular uptake of Neisseria meningitidis in brain endothelial cells

I. Fohmann, A. Weinmann, F. Schumacher, S. Peters, A. Prell, C. Weigel, S. Spiegel, B. Kleuser, A. Schubert-Unkmeir

PLoS Pathog.,  2023

first published: 30 November 2023

The Legionella autoinducer LAI-1 is delivered by outer membrane vesicles to promote interbacterial and interkingdom signaling

The Legionella autoinducer LAI-1 is delivered by outer membrane vesicles to promote interbacterial and interkingdom signaling

M. Fan, P. Kiefer, P. Charki, C. Hedberg, J. Seibel, J. A. Vorholt and H.Hilbi

J. Biol. Chem., 299(12), 105376,  2023

first published: 20 October 2023

DRD1 signaling modulates TrkB turnover and BDNF sensitivity in direct pathway striatal medium spiny neurons

DRD1 signaling modulates TrkB turnover and BDNF sensitivity in direct pathway striatal medium spiny neurons

T. Andreska, P. Lüningschr.r, D. Wolf, R.L. McFleder, M. Ayon-Olivas, M. Rattka, C. Drechsler, V. Perschin, R. Blum, S. Aufmkolk, N. Granado, R. Moratalla, M. Sauer, C. Monoranu, J. Volkmann, C.W. Ip, C. Stigloher and M. Sendtner

Cell Rep, 42(6), 1125752023

first published: 27 June 2023

Development of an Effective Functional Lipid Anchor for Membranes (FLAME) for the Bioorthogonal Modification of the Lipid Bilayer of Mesenchymal Stromal Cells

Development of an Effective Functional Lipid Anchor for Membranes (FLAME) for the Bioorthogonal Modification of the Lipid Bilayer of Mesenchymal Stromal Cells

C. Sternstein, T.-M. Böhm, J. Fink, J. Meyr, M. Lüdemann, M. Krug, K. Kriukov, C. O. Gurdap, E. Sezgin, R. Ebert, J. Seibel

BC Bioconjugate Chemistry,  2023

first published: 16 June 2023

Single-mutations at the galactose-binding site of enzymes GalK, GalU and LgtC enable the efficient synthesis of UDP-6-azido-6-deoxy-D-galactose and azido-functionalized Gb3 analogs

Single-mutations at the galactose-binding site of enzymes GalK, GalU and LgtC enable the efficient synthesis of UDP-6-azido-6-deoxy-D-galactose and azido-functionalized Gb3 analogs

M. E. Ortiz-Soto, M. Baier, D. Brenner, M. Timm and J. Seibel

Glycobiology, 33(8), 651-660,  2023

first published: 7 June 2023

Azido-Ceramides, a Tool to Analyse SARS-CoV-2 Replication and Inhibition—SARS-CoV-2 Is Inhibited by Ceramides

Azido-Ceramides, a Tool to Analyse SARS-CoV-2 Replication and Inhibition—SARS-CoV-2 Is Inhibited by Ceramides

D. Brenner, N. Geiger, J. Schlegel, V. Diesendorf, L. Kersting, J. Fink, L. Stelz, S. Schneider-Schaulies, M. Sauer, J. Bodem, J. Seibel

Int. J. Mol. Sci. 2023, 24(8), 7281

first published: 14 April 2023

Sphingosine as a New Antifungal Agent against Candida and Aspergillus spp.

Sphingosine as a New Antifungal Agent against Candida and Aspergillus spp.

F. Hashemi Arani, S. Kadow, M. Kramer, S. Keitsch, L. Kirchhoff, F. Schumacher, B. Kleuser, P.-M- Rath, E. Gulbins, A. Carpinteiro

Int. J. Mol. Sci. 202223(24), 15510

published: 7 December 2022

Bioorthogonal azido-S1P works as substrate for S1PR1

Bioorthogonal azido-S1P works as substrate for S1PR1

C. Sternstein, J. Schlegel, M. Sauer, J. Seibel

J. Lipid Res. 2023, Vol. 64, Issue 1,  100311, January 01, 2023

first published: 10 November 2022

Antiviral and Anti-Inflammatory Activities of Fluoxetine in a SARS-CoV-2 Infection Mouse Model

Antiviral and Anti-Inflammatory Activities of Fluoxetine in a SARS-CoV-2 Infection Mouse Model

D. Péricat, S. Adonai Leon-Icaza, M. Sanchez Rico, C. Mühle, I. Zoicas, F. Schumacher, R. Planès, R. Mazars, G. Gros, A. Carpinteiro, K. A. Becker, J. Izopet, N. Strub-Wourgaft, P. Sjö, O. Neyrolles, B. Kleuser, F. Limosin, E. Gulbins, J. Kornhuber, E. Meunier, N. Hoertel, C. Cougoule

Int. J. Mol. Sci. 202223(21), 13623

published: 7 November 2022

Lymphatic migration of unconventional T cells promotes site-specific immunity in distinct lymph nodes

Lymphatic migration of unconventional T cells promotes site-specific immunity in distinct lymph nodes

M. A. Ataide, K. Knöpper, P. Cruz de Casas, M. Ugur, S. Eickhoff, M. Zou, H. Shaikh, A. Trivedi, A. Grafen, T. Yang, I. Prinz, K. Ohlsen, M. Gomez de Agüero, A. Beilhack, J. Huehn, M. Gaya, A.-E. Saliba, G.Gasteiger, W. Kastenmüller

Immunity2022

first published: 11 October 2022

The acid ceramidase/ceramide axis controls parasitemia in Plasmodium yoelii-infected mice by regulating erythropoiesis

The acid ceramidase/ceramide axis controls parasitemia in Plasmodium yoelii-infected mice by regulating erythropoiesis

A. Günther, M. Hose, H. Abberger, F. Schumacher, Y. Veith, B. Kleuser, K. Matuschewski, K. S. Lang, E. Gulbins, J. Buer, A. M. Westendorf, W. Hansen

eLife 2022; 11:e77975.

published: 12 September 2022

The Acid Ceramidase Is a SARS-CoV-2 Host Factor

The Acid Ceramidase Is a SARS-CoV-2 Host Factor

N. Geiger; L. Kersting.; J. Schlegel; L. Stelz; S. Fähr; V. Diesendorf; V. Roll; M. Sostmann; E.-M. König; S. Reinhard; D. Brenner; S. Schneider-Schaulies; M. Sauer; J. Seibel; J. Bodem

Cells 202211, 2532.

published: 15 August 2022

Synthesis and Characterization of Ceramide-Containing Liposomes as Membrane Models for Different T Cell Subpopulations

Synthesis and Characterization of Ceramide-Containing Liposomes as Membrane Models for Different T Cell Subpopulations

S. Eder, C. Hollmann, P. Mandasari, P. Wittmann, F. Schumacher, B. Kleuser, J. Fink, J. Seibel, J. Schneider-Schaulies, C. Stigloher, N. Beyersdorf, S. Dembski

J. Funct. Biomater. 2022, 13(3), 111

published: 2 August 2022

Rocaglates as Antivirals: Comparing the Effects on Viral Resistance, Anti-Coronaviral Activity, RNA-Clamping on eIF4A and Immune Cell Toxicity

Rocaglates as Antivirals: Comparing the Effects on Viral Resistance, Anti-Coronaviral Activity, RNA-Clamping on eIF4A and Immune Cell Toxicity

W. Obermann, A. Friedrich, R. Madhugiri, P. Klemm, J. P. Mengel , T. Hain, S. Pleschka, H.-G. Wendel, R. K. Hartmann, S. Schiffmann, J. Ziebuhr, C. Müller, A. Grünweller 

Viruses2022

first published: 03 March 2022

Inhibition of SARS-CoV-2 coronavirus proliferation by designer antisense-circRNAs

Inhibition of SARS-CoV-2 coronavirus proliferation by designer antisense-circRNAs

C. Pfafenrot, T. Schneider, C. Müller, L.-H. Hung, S. Schreiner, J. Ziebuhr, A. Bindereif

Nucleic Acids Res.2021

first published: 24 November 2021

A Comprehensive Review on the Interplay between Neisseria spp. and Host Sphingolipid Metabolites

A Comprehensive Review on the Interplay between Neisseria spp. and Host Sphingolipid Metabolites

S. Peters, I. Fohmann, T. Rudel, A. Schubert-Unkmeir

Cells 2021, 10, 3201

published: 17 November 2021

The Manifold Roles of Sphingolipids in Viral Infections

The Manifold Roles of Sphingolipids in Viral Infections

E. Avota , J. Bodem , J. Chithelen , P. Mandasari , N. Beyersdorf and J. Schneider-Schaulies

Front. Physiol.

published: 29 September 2021

Sphingolipids: Effectors and Achilles Heals in Viral Infections?

Sphingolipids: Effectors and Achilles Heals in Viral Infections?

S. Schneider-Schaulies, F. Schumacher, D. Wigger, M. Schöl, T. Waghmare, J. Schlegel, J. Seibel and B. Kleuser

Cells 2021, 10(9), 2175

published: 24 August 2021

 

Staphylococcus aureus a-Toxin Induces Acid Sphingomyelinase Release From a Human Endothelial Cell Line

Staphylococcus aureus a-Toxin Induces Acid Sphingomyelinase Release From a Human Endothelial Cell Line

D. Krones, M. Rühling, K. A. Becker, T. C. Kunz, C. Sehl, K. Paprotka, E. Gulbins, M. Fraunholz

Front. Microbiol.

published: 29 July 2021

Editorial: Sphingolipids in Infection Control

Editorial: Sphingolipids in Infection Control

J. Seibel, S. Schneider-Schaulies, B. Kleuser

Front. Cell Dev. Biol.

published: 21 June 2021

Intracellular persistence of Staphylococcus aureus in endothelial cells is promoted by the absence of phenol-soluble modulins

Intracellular persistence of Staphylococcus aureus in endothelial cells is promoted by the absence of phenol-soluble modulins

A. Siegmund, M. A. Afzal, F. Tetzlaff, D. Keinhörster, F. Gratani, K. Paprotka, M. Westermann, S. Nietzsche, C. Wolz, M. Fraunholz, C. A. Hübner, B. Löffler, L. Tuchscherr

Virulence, Volume 12, 2021, Issue 1

published: 12 April 2021

Inhibition of acid sphingomyelinase increases regulatory T cells in humans

Inhibition of acid sphingomyelinase increases regulatory T cells in humans

T. Wiese, F. Dennstädt, C. Hollmann, S. Stonawski, C. Wurst, J. Fink, E. Gorte, P. Mandasari, K. Domschke, L. Hommers, B. Vanhove, F. Schumacher, B. Kleuser, J. Seibel, J. Rohr, M. Buttmann, A. Menke, J. Schneider-Schaulies, N. Beyersdorf

Brain Communications, Volume 3, Issue 2, 2021

published: 5 March 2021

The Expandables: Cracking the Staphylococcal Cell Wall for Expansion Microscopy

The Expandables: Cracking the Staphylococcal Cell Wall for Expansion Microscopy

T. Kunz, M. Rühling, A. Moldovan, K. Paprotka, V. Kozjak-Pavlovic, T. Rudel, M. Fraunholz

Front. Cell. Infect. Microbiol. 11:644750

published: 16 March 2021

Click-correlative light and electron microscopy (click-AT-CLEM) for imaging and tracking azido-functionalized sphingolipids in bacteria

Click-correlative light and electron microscopy (click-AT-CLEM) for imaging and tracking azido-functionalized sphingolipids in bacteria

S. Peters, L. Kaiser, J. Fink, F. Schumacher, V. Perschin, J. Schlegel, M. Sauer, C. Stigloher, B. Kleuser, J. Seibel and A. Schubert-Unkmeir

Scientific Reports 2021, 11, 4300

published: 22nd February 2021

Azidosphinganine enables metabolic labeling and detection of sphingolipid de novo synthesis

Azidosphinganine enables metabolic labeling and detection of sphingolipid de novo synthesis

J. Fink, F. Schumacher, J. Schlegel, P. Stenzel, D. Wigger, M. Sauer, B. Kleuser and J. Seibel

Org. Biomol. Chem., 2021

published: January 2021

Nanoscale imaging of bacterial infections by sphingolipid expansion microscopy

Nanoscale imaging of bacterial infections by sphingolipid expansion microscopy

R. Götz, T. C. Kunz, J. Fink, F. Solger, J. Schlegel, J. Seibel, V. Kozjak-Pavlovic, T- Rudel, M. Sauer

Nature Communications

published: 2nd December 2020

Modulation of Host Cell Death and Lysis Are Required for the Release of Simkania negevensis

Modulation of Host Cell Death and Lysis Are Required for the Release of Simkania negevensis

R.-D. Koch, E.-M. Hörner, N. Münch, E. Maier, V. Kozjak-Pavlovic 

Front. Cell. Infect. Microbiol.

published: 29 October 2020

Detection of Functionalized Sphingolipid Analogs in Detergent-Resistant Membranes of Immune Cells

Detection of Functionalized Sphingolipid Analogs in Detergent-Resistant Membranes of Immune Cells

Fink J., Seibel J., Avota E. 

Bieberich E. (eds) Lipid Rafts. Methods in Molecular Biology, vol 2187. Humana, New York, NY

published: August 2020

High-Yielding Water-Soluble Asymmetric Cyanine Dyes for Labeling Applications

High-Yielding Water-Soluble Asymmetric Cyanine Dyes for Labeling Applications

N. Wolf, L. Kersting, C. Herok, C. Mihm, J. Seibel

J. Org. Chem. 2020, 85, 15, 9751-9760

published: 20 July 2020

Acid ceramidase of macrophages traps herpes simplex virus in multivesicular bodies and protects from severe disease

Acid ceramidase of macrophages traps herpes simplex virus in multivesicular bodies and protects from severe disease

Lang, J., Bohn, P., Bhat, H. et al.

Nat Commun 11, 1338 (2020).

published: March 2020