Deutsch Intern
Rudolf Virchow Center for Integrative and Translational Bioimaging

TESSMER Gruppe

Molecular Mechanisms of DNA repair

DNA repair is fundamentally important for the maintenance of cellular genetic stability. DNA damages arise continuously through endogenous factors (such as errors in DNA replication or metabolic products within our cells) as well as exogenous sources (such as high energy radiation). The resulting defects in DNA can lead to mutations and ultimately cancer or to cell death and hence must be removed by highly efficient DNA repair mechanims. To maintain genomic stability cells exploit several DNA repair systems: base excision repair (BER), nucleotide excision repair (NER),  DNA double strand break repair by homologous recombination or non-homologous end joining, mismatch repair (MMR) and direct damage reversal. These DNA repair systems are each specialised on the recognition and removal of specific types of DNA lesions and are mostly evolutionary conserved.

In our research group we use single molecule fluorescence and atomic force microscopy (AFM) complemented by biochemical and biophysical assays to investigate the molecular mechanisms of diverse DNA repair systems. In particular, we are interested in understanding the strategies of protein-DNA interactions to achieve selective recognition and repair of different types of DNA lesions and in the interplay between different DNA processing systems.  

AG Tessmer

PD Dr. Ingrid Tessmer

Gruppenleiterin
Rudolf-Virchow-Zentrum - Center for Integrative and Translational Bioimaging, Early Independence Program
Universität Würzburg
Josef-Schneider-Str.2
97080 Würzburg
Deutschland
Building: Haus D15
Room: 00.046
Phone: +49 931 31-80425
Fax: +49 931 31-83255
ORCID: https://orcid.org/0000-0002-8353-6315

Anil Singh Kumar

PhD Student
Rudolf-Virchow-Zentrum - Center for Integrative and Translational Bioimaging
Universität Würzburg
Josef-Schneider-Straße 2
97080 Würzburg
Deutschland
Building: Haus D15
Phone: 0931 31-80844

Pathoja Maity

PhD Studentin
Rudolf-Virchow-Zentrum - Center for Integrative and Translational Bioimaging
Universität Würzburg
Josef-Schneider-Str. 2
97080 Würzburg
Phone: +49 931 31-83763

 

 

In addition, the following people are currently supporting our team:

Kürsat Atmaca - Erasmus student

Johanna Brandl - Bachelor student

Maisaa Alsaleh - Bachelor student (external, University of Applied Sciences Köln)

All  publications can be found here.

Current position

Group leader, University of Würzburg, Germany (since 2014)

Research Experience

2008-2013 Early Independence Program, University of Würzburg, Germany
2007-2008 Postdoctoral Researcher, University of Würzburg, Germany
2003-2007 Postdoctoral Fellow, University of North Carolina (UNC), USA

Education

2014-2017 Habilitation in Biophysics (German eligibility for professorship) Department of Biology, University of Würzburg, Germany
1999-2003 PhD in Biophysics, University of Nottingham, UK

Mitglied

  • Graduate School of Life Sciences
  • Biologische Fakultaet
  • Supervisor und Mitglied in Promotionskomittee

Lehrveranstaltungen

  • Literaturseminar DNA Reparatur (für Masterstudenten und Doktoranden, Vorlesungsverzeichnis # 0732348)
  • Export Lehre der biologischen Fakultät für Mediziner (06070100 und 06070110 für die begleitenden Übungen)
  • Studienbegleitende Mitarbeiten im Forschungslabor (für Bachelor- und Masterstudenten, Vorlesungsverzeichnis # 03980410 und 03980460) 
  • Seminar für Doktoranden, Master- und Bachelorstudenten (Vorlesungsverzeichnis # 03988110)
  • Anleitung zum selbstständigen wissenschaftlichen Arbeiten (Vorlesungsverzeichnis # 03988120)
  • Biophysik und molekulare Biotechnologie (für Masterstudenten, Vorlesungsverzeichnis # 129350, Beitäge) bis SS 2019
  • Biophysik und Biochemie (für Masterstudenten, Vorlesungsverzeichnis # 129351, Beiträge) bis WS 2019/20