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Deutsch Intern
Rudolf Virchow Center for Experimental Biomedicine

About the Boettcher Group

We use and develop high-resolution electron cryo microscopy and image processing to understand how biological complexes work. In particular we are interested in the modular organization, which enables complex functionalities by combining various modules with different properties into a single entity.  

Structural dynamics of Biological Complexes

To learn more about the unifying structural principles of complex functionality we study many different types of complexes in different functional states. Among these complexes are mechanosensitive channels of small conductance. Here we want to elucidate how the interplay between proteins and lipids enables gating and mechanosensation.  Other complexes include viral capsids, for which we want to clarify the structural mechanisms of signalling and viral maturation.

Website Chair of Biochemistry

Capabilities of the Falcon III detector for single-particle structure determination. Song, B., J. Lenhart, V. J. Flegler, C. Makbul, T. Rasmussen and B. Böttcher (2019). Ultramicroscopy 203: 145-154. https://www.ncbi.nlm.nih.gov/pubmed/30738626

Structure of Mutant Hepatitis B Core Protein Capsids with Premature Secretion Phenotype.Böttcher B. and Nassal M. (2018). J Mol Biol 430 4941–54. doi: 10.1016/j.jmb.2018.10.018.

Geometrical and Structural Dynamics of Imatinib within Biorelevant Colloids. Wiest J., Saedtler M., Böttcher B., Grune M., Reggane M., Galli B., Holzgrabe U. and Meinel L. (2018). Mol Pharm Aug 28; 15 4470-80. doi: 10.1021/acs.molpharmaceut.8b00469.

Near-Atomic Resolution Structure of a Plant Geminivirus Determined by Electron Cryomicroscopy. Hipp K., Grimm C., Jeske H. and Böttcher B. (2017). Structure Aug 01; 25 (8): 1303-9 e3. doi: 10.1016/j.str.2017.06.013.

Structural reorganization of the chromatin remodeling enzyme Chd1 upon engagement with nucleosomes. Sundaramoorthy R., Hughes A. L., Singh V., Wiechens N., Ryan D. P., El-Mkami H., Petoukhov M., Svergun D. I., Treutlein B., Quack S., Fischer M., Michaelis J., Böttcher B., Norman D. G. and Owen-Hughes T. (2017). Elife Mar 23; 6 doi: 10.7554/eLife.22510.

Biophysical characterization and activity of lymphostatin, a multifunctional virulence factor of attaching & effacing Escherichia coli. Cassady-Cain R. L., Blackburn E. A., Alsarraf H., Dedic E., Bease A. G., Böttcher B., Jorgensen R., Wear M. and Stevens M. P. (2016). J Biol Chem Jan 19; 291 5803-16. doi: 10.1074/jbc.M115.709600.

Cathelicidins Have Direct Antiviral Activity against Respiratory Syncytial Virus In Vitro and Protective Function In Vivo in Mice and Humans. Currie S. M., Gwyer Findlay E., McFarlane A. J., Fitch P. M., Böttcher B., Colegrave N., Paras A., Jozwik A., Chiu C., Schwarze J. and Davidson D. J. (2016). J Immunol Mar 15; 196 (6): 2699-710. doi: 10.4049/jimmunol.1502478.

Prof.'in Dr. Bettina Böttcher

Josef-Schneider-Straße 2
97080 Würzburg
Building: Haus D15
Phone: 0931 31-84193

Vanessa Flegler

Doktorandin
Rudolf-Virchow-Zentrum für Experimentelle Biomedizin
Universität Würzburg
Josef-Schneider-Str. 2
97080 Würzburg
Deutschland
Building: Haus D15
Room: 00.011

Dr. Cihan Makbul

Postdoc
Rudolf-Virchow-Zentrum für Experimentelle Biomedizin
Universität Würzburg
Josef-Schneider-Str. 2
97080 Würzburg
Deutschland
Building: Haus D15
Room: 00.011

Dr. Akiko Rasmussen

Postdoc
Rudolf-Virchow-Zentrum für Experimentelle Biomedizin
Universität Würzburg
Josef-Schneider-Str. 2
97080 Würzburg
Deutschland
Building: Haus D15
Room: 00.011

Dr. Tim Rasmussen

PostDoc
Rudolf-Virchow-Zentrum für Experimentelle Biomedizin
Universität Würzburg
Josef-Schneider-Str. 2
97080 Würzburg
Deutschland
Building: Haus D15
Room: 00.011

Boyuan Sam Song

Doktorand
Rudolf-Virchow-Zentrum für Experimentelle Biomedizin
Universität Würzburg
Josef-Schneider-Str. 2
97080 Würzburg
Deutschland
Building: Haus D15
Room: 00.011

Current position

 

Professor for Biochemistry with Focus on Electron Cryo Microscopy at the Julius-Maximilians University Würzburg (since 2016).

Research Experience

since 2016

Professor for Biochemistry with Focus on Electron Cryo Microscopy at the Julius-Maximilians University Würzburg

2013-2016

Personal Chair in Electron Microscopy and Image Processing at the University of Edinburgh, School of Biological Sciences

2010-2016

Head of the Cryo-EM facility in Edinburgh

2008-2013

Reader at the University of Edinburgh, School of Biological Sciences

1999-2008

Group leader at the EMBL-Heidelberg

1996-1999

C1-position in Physical Chemistry at the Albert-Ludwigs University Freiburg

1992-1996

PostDoc at the Laboratory of Molecular Biology, Medical Research council, Cambridge UK

 

Education

2002

Habilitation; Venia Legendi in Physical Chemistry; Albert-Ludwigs-Universität Freiburg

1991

Dr. rer. nat.: University Stuttgart

 

Editorial Work

Since 2017

Member of the Faculty of 1000

since 2014

since 2012

Member of the editorial board of PeerJ

Member of the Editorial Board of Scientifica

 

Honors and Awards

2008-2013

Darwin-Trust Senior Research Fellow

2000

1998

Ernst Ruska Prize for Electron Microscopy

Boris-Rajewsky Prize for Biophysics

1995-1996

Human Capital and Mobility fellowship (EU)

1994

EMBO-Fellowship

1992-1993

DFG-Research Fellowship

Lecture/ seminar in imaging techniques in the life sciences

Literature seminar `Electron Microscopy in Structural Biology`

Methods in Life Sciences (Focus Lecture)

Lecture /Seminar Electron microscopy and image processing in structural biology

Internship Electron microscopy und imaging techniques