Our intestinal tract offers an attractive environment for both beneficial and pathogenic bacteria. The beneficial bacteria of our microbiota feast on undigested foods and provide numerous health benefits. Enteric pathogens see this environment as an entry point for infection. Both groups influence each other, creating a tripartite interaction with us, the host. Understanding the regulatory processes that decide on the outcome of these encounters represents an emerging research area to combat infectious diseases. While the field has focused on protein-mediated processes, our group investigates the role of RNA-centric mechanisms in controlling microbial interactions in the gut.
Ryan D, Jenniches L, Reichardt S, Barquist L, Westermann AJ (2020)
A high-resolution transcriptome map identifies small RNA regulation of metabolism in the gut microbe Bacteroides thetaiotaomicron.
Nature Communications 11(1):3557
Westermann AJ, Förstner KU, Amman F, Barquist L, Chao Y, Schulte LN, Müller L, Reinhardt R, Stadler PF, Vogel J (2016)
Dual RNA-seq unveils noncoding RNA functions in Salmonella-host interplay
Stapels DAC, Hill PWS, Westermann AJ, Fisher R, Thurston TL, Saliba A-E, Blommestein I, Vogel J, Helaine S (2018)
Salmonella persisters undermine host immune defences during antibiotic treatment
Jiao C, Reckstadt C, König F, Homberger C, Yu J, Vogel J, Westermann AJ, Sharma CM, Beisel CL (2023)
RNA recording in single bacterial cells using reprogrammed tracrRNAs
Nature Biotechnology (Online ahead of print)
Schuster E-M, Epple MW, Bremser A, Lucht K, Zimmermann J, Polyzou A, Ballabio A, Trompouki E, Vogel J, Büscher J, Westermann AJ, Rambold AS (2022)
TFEB induces mitochondrial itaconate synthesis to suppress bacterial growth in macrophages.
Nature Metabolism 4(7):856-866