piwik-script

English Intern
Rudolf-Virchow-Zentrum - Center for Integrative and Translational Bioimaging

AG Thorn

Über die AG Thorn

Molekülstrukturen sind die Grundlage der modernen Biochemie. Sie erlauben uns zum Beispiel zu verstehen, wie Vererbung funktioniert (DNA-Doppelhelix) oder neue Arzneimittel zu finden (Zika-Virus). Aber diese Strukturen können nicht direkt gemessen werden, sondern die Bilddaten müssen mit einem Strukturmodell abgeglichen werden. Je besser das Modell und die Daten zusammenpassen, desto mehr neue, anspruchsvollere Strukturen können wir damit lösen und mit ihnen wichtige biologische Fragen beantworten. Das ist die treibende Kraft hinter unserer Arbeit.

Kristallographie: Bessere Modelle und Daten

In unserer Forschungsgruppe finden wir neue Methoden für die Strukturbestimmung mittels Röntgenkristallographie und Kryo-Elektronenmikroskopie; wir verbessern Molekül-Modelle und auch die Software, mit der diese Modele gebaut werden können; in Zusammenarbeit mit verschiedenen Teilchenbeschleunigern verbessern wir die Messung und Verarbeitung von Röntgendaten und wir verwenden neuronale Netzwerke, um elektronenmikroskopische Aufnahmen besser zu interpretieren.

Dr. Thorn's Arbeitsgruppe ist Teil derForschungsgruppe Schindelin.

17 Jun 2020

We are looking for a PhD student candidate for a challenging and rewarding project improving how we model X-ray structures in general. Deadline 26 Jul 2020: PhD job offer (pdf download).


14 May 2020

TV Interview zur Coronaforschung am RVZ

Heute, 18:00 Uhr, berichtet unsere RVZ Wissenschaftlerin Dr. Andrea Thorn (Rudolf-Virchow-Zentrum der Universität Würzburg) auf dem TV-Sender TV Mainfranken über die Forschung ihres internationalen Netzwerks - der "Coronavirus Structural Taskforce". more


23 Apr 2020

TV Interview zur Erforschung des Coronavirus am RVZ

Heute, um 17:30 Uhr, berichtet unsere RVZ Wissenschaftlerin Dr. Andrea Thorn (Rudolf-Virchow-Zentrum der Universität Würzburg) auf dem TV-Sender SAT.1 Bayern über ihre Leitung des internationalen Netzwerks zur Erforschung des Coronavirus - die "Coronavirus Structural Taskforce" more


20 Apr 2020

Coronavirus: finding the weak spot

Dr. Andrea Thorn, a structural biologist from Würzburg, is leading an international coronavirus research network. The results of her work are important for developing vaccines and drugs. more


19 Dec 2019

We are looking for a PhD student and Postdoc candidate for a challenging and rewarding project improving how we model X-ray structures in general. Deadline 31 Jan 2020: PhD job offer (pdf-download) & Postdoc job offer (pdf-download)


18 - 23 Aug 2019

At the European Crystallographic Meeting in Vienna, we will present our new software Haruspex for secondary structure prediction in Cryo-EM. AUSPEX will be demonstrated in the ECM Software Fayre and we will give an additional talk on"It’s just like planning a dinner...” - Women in Crystallographic Computing' and co-organize the European Crystallographic Computing Forum (ECM Satellite Meeting).

 


24 July 2019

We are looking for a post-doctoral researcher! Uncover pitfalls in the measurement of modern XFEL, neutron and conventional X-ray data. Develop new diagnostics using statistical tools and machine learning. Deadline 8 Sep 2019 More details


9 July 2019

AUSPEX poster shown at the Royal Society: AUSPEX was selected as one of the affiliated research projects to be presented at the 40th anniversary of the English software initiative CCP4.


8 July 2019

The German Federal Ministry for Research and Education (BMBF) agreed to fund the project „New Diagnostics for Macromolecular Structure Determination at Large Facilities: AUSPEX”. Press release

Mostosi, P., Schindelin, H., Kollmannsberger, P., Thorn*, A. (2019) Automated interpretation of Cryo-EM density maps with convolutional neural networks. www.biorxiv.org/content/10.1101/644476v1 DOI: 10.1101/644476 [preprint]


Thorn, A., Parkhurst, J.M., Emsley, P., Nicholls, R., Evans, G., Vollmar, M., Murshudov, G.N. (2017) AUSPEX: a graphical tool for X-ray diffraction data analysis, Acta Cryst D73 729-737.


Parkhurst, J.M., Thorn, A., Vollmar, M., Winter, G., Waterman, D.G., Fuentes-Montero, L., Gildea, R.J., Murshudov G.N., Evans, G. (2017) Background modelling of diffraction data in the presence of ice-rings, IUCrJ 4, 626-638.


Thorn, A. (2017) Experimental Phasing: Substructure Solution and Density Modification as Implemented in SHELX, in Protein Crystallography, Methods in Molecular Biology (series), 357-376 co-editors A. Wlodawer, Z. Dauter, and M. Jaskolski, Springer. [invited book chapter]


Knott, G.J, Panjikar, S., Thorn, A., Fox, A.H., Conte, M.R., Lee, M., Bond, C.S. (2016) A crystallographic study of human NONO (p54nrb): Overcoming pathological problems with purification, data collection and non-crystallographic symmetry, Acta Cryst. D72, 761-769


Deigan Warner, K.D., Chen, M.C., Song, W., Strack R.L., Thorn, A., Jaffrey S.R., Ferré-D’Amaré, A.R. (2014) Structural basis for activity of highly efficient RNA mimics of green fluorescent protein , Nature Structural & Molecular Biology 21, 658–663


Thorn, A., Sheldrick G.M. (2013) Extending Molecular Replacement Solutions with SHELXE , Acta Cryst. D. 69, 2251-2256


Cooper, R.I., Thorn, A., Watkin D.J. (2012) CRYSTALS enhancements: asymmetric restraints, J. Appl. Cryst. 45, 1057-1060


Thorn, A., Steinfeld, R., Ziegenbein, M., Grapp, M., Hsiao, H.H., Urlaub, H., Sheldrick, G.M., Gärtner, J., Krätzner, R. (2012) Structure and activity of the only human RNase T2, Nucleic Acids Res. 40, 8733-8742


Thorn, A., Dittrich, B., Sheldrick, G.M. (2012) Enhanced rigid-bond restraints, Acta Cryst. A68, 448-451


Thorn, A., Sheldrick, G.M. (2011) ANODE: ANOmalous and heavy-atom DEnsity calculation, J. Appl. Cryst. 44, 1285-1287


Tavcar, G., Sen, S.S., Azhakar, R., Thorn, A., Roesky, H.W. (2010) Facile syntheses of silylene nickel carbonyl complexes from Lewis base stabilized chlorosilylenes Inorg Chem. 49, 10199-10202


Vouffo, B., Dongo, E., Facey, P., Thorn, A., Sheldrick, G. M., Maier, A., Fiebig, H.H., Laatsch, H. (2010) Antiarol cinnamate and Africanoside, a cinnamoyl triterpene and a hydroperoxy-cardenolide from the stem bark of Antiaris africana, Planta Med. 76, 1717-1723


Fischer, A., Stern, D., Thorn, A., Abraham, S., Stalke, D., Klingebiel, U. (2010) From the Lithium-2-anilide-2-fluoro-1,3-diaza-2-sila-cyclopentene-GaCl3 Adduct to 1,4,6-Triaza-5-gallium-7-sila-cyclo-3-heptene - Experimental and Quantum-chemical Results Z. Anorg. Allg. Chem. 636 (2010), 1527-1532


Vollmar, D., Thorn, A., Schuberth, I., Grond, S. (2009) A comprehensive view on 4-methyl-2-quinazolinamine, a new microbial alkaloid from Streptomyces of TCM plant origin, J. Antibiot. 62, 439-444


Thorn, A., Egerer-Sieber, C., Jäger, C.M., Herl, V., Müller-Uri, F., Kreis, W., Muller Y.A. (2008) The crystal structure of 5β-Progesterone Reductase from Digitalis Lanata defines of a novel subfamily of short-chain dehydrogenases/reductases, J. Biol. Chem. 283, 17260-17269


Tampier, S., Müller, R., Thorn, A., Hübner, E., Burzlaff, N. (2008) Synthesis, Structure and Reactivity of Ruthenium Carboxylato and 2-Oxocarboxylato Complexes bearing the Bis(3,5-dimethylpyrazol-1-yl)acetato Ligand, Inorg Chem. 47 , 9624-9641

 

Dr. Yunyun Gao

Postdoc
Rudolf-Virchow-Zentrum - Center for Integrative and Translational Bioimaging
Universität Würzburg
Josef-Schneider-Str. 2
97080 Würzburg
Gebäude: Haus D15
Telefon: +49 931 31-87267

Dr. Matthew Reeves

Postdoc
Rudolf-Virchow-Zentrum - Center for Integrative and Translational Bioimaging
Universität Würzburg
Josef-Schneider-Straße 2
97080 Würzburg
Gebäude: Haus D15
Telefon: +49 931 31-87483

Dr. Andrea Thorn

Rudolf-Virchow-Zentrum - Center for Integrative and Translational Bioimaging
Universität Würzburg
Josef-Schneider-Str. 2
97080 Würzburg
Deutschland
Gebäude: Haus D15
Raum: 00.042
Telefon: +49 931 31-83677

Current position

Junior group leader in the lab of Prof. Hermann Schindelin at the Rudolf Virchow Center of  University of Würzburg (since 2019)

Research Experience

2017-2019

Postdoctoral researcher in the research group of Prof. Hermann Schindelin, University of Würzburg, Germany

2016-2017

Postdoctoral researcher, University of Hamburg, Germany

2016

Senior Research Scientist, Diamond Lightsource, Oxford, UK

2013-2016

Investigator Scientist, MRC Laboratory of Molecular Biology, Cambridge, UK

2013

Post-doctoral research associate, University of Cambridge, UK

2011-2012

Postdoctoral researcher, Georg-August University Goettingen, Germany

Education

2008-2011

Dr. rer. nat, Georg-August University Goettingen, Germany (supervisor: Prof. George M. Sheldrick)

Fellowships, Awards and External Funding

  • BMBF „Erforschung der Materie an Großgeräten“ (2019)
  • DFG Sachbeihilfe (2019)
  • Rising Star Award, Asian Crystallographic Association (2013)
  • Marie-Curie IEF Fellowship (2013)

Selected activities

  • Vice president Computing Interest Group of the European Crystallographic Association (since 2018)
  • Member  of the IUCr Computing Commission (since 2017)
  • Scientific program director for the European Crystallographic Computing Forum 2018, Spain
  • Scientific program director for the European Computing School in Germany 2016 and in Croatia 2015
  • Council Member of the British Crystallographic Association (2013-2016)
  • Secretary Computing Interest Group of the European Crystallographic Association (2013-2018)

Mitglied in der - Graduate School of Life Sciences

Dr. Thorn hält jedes Jahr Vorträge in verschiedenen internationalen Kursen::

  • SeaCoast workshop (South East Asia) (January)
  • RapiData at Stanford Synchrotron Radiation Lightsource, US (April)
  • Cold Spring Harbor Course "Diffraction Methods", US (October)
  • Diamond-CCP4 Data Collection and Structure Solution Workshop in Oxfordshire, UK (December)
  • International CCP4 courses (varying dates and places)