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Rudolf-Virchow-Zentrum für Experimentelle Biomedizin

Bachelor- und Masterarbeiten

Sofern Kapazitäten frei sind, können Projekte für Bachelor- und Masterarbeiten angeboten werden. Dies liegt im Ermessen der jeweiligen Arbeitsgruppe. Bitte informieren Sie sich daher über die wissenschaftlichen Schwerpunkte der einzelnen Forschungsgruppen und wenden Sie sich direkt an den Forschungsgruppenleiter per Email.

MASTER THESIS project in cellular super-resolution microscopy

The Rudolf Virchow Center for Experimental Biomedicine of the University of Würzburg is currently searching for a highly motivated

Master student (f/m)
(Biology / Biomedicine / Biophysics)
for a MASTER THESIS project
Mirror-enhanced STORM (meSTORM) in the field of cellular super-resolution microscopy

In a cross-disciplinary approach we combine high-resolution concepts of fluores-cence microscopy with tricks from material sciences.
The master thesis project involves optimization of the buffer environment for superresolution microscopy that enhances the fluorescence signal on our tailor-made biocompatible nanocoated coverslips. The overall goal is to resolve the architecture and dynamics of cytoskeletal (sub-)structures that are not accessi-ble using classic fluorescence imaging. The project particularly requires enthusiasm for biomolecular sciences and super-resolution microscopy.

Please, contact: katrin.heinze@virchow.uni-wuerzburg.de,
Prof. Dr. Katrin Heinze, RVZ, Josef-Schneider-Str. 2 (D15), 97080 Würzburg
https://www.uni-wuerzburg.de/en/rvz/research/research-groups/heinze-group/

Master thesis project in structural biology

Master thesis project in the Institute for Structural Biology at the Rudolf Virchow Center for Experimental Biomedicine

The Grabarczyk group is looking for a motivated and enthusiastic Master student to work on the molecular mechanisms of the DNA replication stress response.

The progress of DNA replication forks is constantly hindered by DNA damage, metabolite depletion and conflicts with transcription. This results in stalled forks which must be stabilised to prevent destructive fork collapse and be signalled to block cell cycle progression under high-stress conditions. Replication stress is emerging as a major hallmark of cancer by linking increased cell proliferation to genomic instability.

Despite its pathophysiological importance, the mechanisms of the replication stress response are poorly understood. In part, this is because the replication fork is a highly dynamic and flexible assembly that is challenging to characterise structurally. To overcome this, we employ an integrative structural biology approach combining X-ray crystallography, cryo-EM, biophysical techniques, peptide microarrays, atomic force microscopy and protein biochemistry. We have successfully implemented this approach to decipher the function of the Ctf18-RFC complex (Grabarczyk et al. Structure 2018).

This specific project will involve elucidating the function of the fork protection complex Tof1-Csm3 using a wide range of methods. The student will benefit from the productive, collaborative and international environment of the Institute for Structural Biology.

If interested, please contact Dr. Daniel Grabarczyk: daniel.grabarczyk@virchow.uni-wuerzburg.de

Open Position for Master Student

The Chair of Experimental Biomedicine, located in the building of the Rudolf Virchow Center for Experimental Biomedicine in Würzburg, is currently searching for a highly motivated Master student.

The project is focusing on the actin cytoskeleton of platelets. The intracellular actin cytoskeleton participates in a large variety of cellular processes such as cytokinesis, cell motility and polarization, phago- and exocytosis. These processes critically depend on a dynamic behavior to depolymerize existing filamentous (F-) actin filaments to replenish the globular (G-) actin pool and on the contrary to build new actin filaments- a system tightly regulated by a plethora of different proteins. Consequently, cytoskeletal protein aberrations are the underlying reason for many pathological phenotypes.

The aim of the master thesis is to characterize the impact of a genetic knockout of a specific cytoskeletal protein on platelet function and biogenesis in transgenic mice. The project comprises a broad range of different methods; among these are Animal models, FACS, Microscopy and Molecular Biology.

Our group offers the possibility to work in an excellent scientific environment but also in an excellent working atmosphere.

If interested, please contact Inga Scheller per E-Mail: E_Birkholz_I@ukw.de

Rudolf-Virchow-Zentrum für Experimentelle Biomedizin
Universität Würzburg
Josef- Schneider-Str. 2
97080 Würzburg
Deutschland

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Rudolf-Virchow-Zentrum für Experimentelle Biomedizin
Josef-Schneider-Straße 2
Haus D15
97080 Würzburg

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