GRK 2243 "Understanding Ubiquitylation: From Molecular Mechanisms to Disease"

    Sonja Lorenz (vice-spokesperson)

    Dr. Sonja Lorenz

    Rudolf Virchow Center for Experimental Biomedicine
    University of Würzburg
    Josef-Schneider-Str. 2, D15
    D-97080 Würzburg

    Tel.: 0931 31-80526
    Fax.: 0931 31-805260

    Email: sonja.lorenz@virchow.uni-wuerzburg.de
    Web: www.virchow-zentrum.uni-wuerzburg.de

    Research Area:
    Structural Biology, Biochemistry

    The Lorenz lab explores the molecular mechanisms of ubiquitylating enzymes including their substrate and linkage specificities, their regulation, their cross-talk with other types of posttranslational modifications, and their potential as therapeutic targets. Studies within the research training group GRK 2243 focus on ubiquitin-conjugating (E2) enzymes and HECT-type ubiquitin ligases (E3 enzymes) with critical links to human cancerogenesis. The Lorenz lab combines structural biology (X-ray crystallography, NMR spectroscopy) with biophysical and biochemical approaches to characterize protein-protein interactions. Cell-based analyses are performed in collaboration with the Eilers and Popov labs.

    Research projects: Project A2, Project C3