GRK 2243 "Understanding Ubiquitylation: From Molecular Mechanisms to Disease"

    Elmar Wolf

    Prof. Dr. Elmar Wolf

    Department of Biochemistry and Molecular Biology
    University of Würzburg
    Am Hubland
    D-97074 Würzburg

    Tel.: 0931 31-83259
    Fax.: 0931 31-84113

    Email: elmar.wolf@biozentrum.uni-wuerzburg.de
    Web:  www.biozentrum.uni-wuerzburg.de/molbio/research-groups/ag-wolf

    Research Area:
    Biochemistry, Tumor Biology, Systems Biology

    Cancer presents an eminent burden of disease worldwide and a pressing need for innovative therapeutic strategies. Deregulated transcription is a hallmark of oncogenic transformation. We study how the transcription machinery is composed and regulated in cancer cells.  While ubiquitylation and degradation of Pol2 is functionally important to remove arrested Pol2 from damaged DNA, the role of ubiquitylation in transcription in unstressed cells is stillunderexplored. Here, we will investigate the impact and mechanistic details of Pol2 ubiquitylation in mammalian cells.

    Research projects: Project C5