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Intern
    Graduiertenkolleg 2157

    Prof. Dr. Sibylle Schneider-Schaulies

    Dept. of Virology
    University of Würzburg
    Versbacher Straße 7
    D-97078 Würzburg

    Tel.: 0931 31 81 566
    Fax: 0931 31 81 611

    Email: s-s-s@vim.uni-wuerzburg.de
    Web: www.virologie.uni-wuerzburg.de


    Research Area:
    Infection Biology, Cellular Immunology, Cell Biology

    Severe complications associated with Measles Virus (MV) infections affect the respiratory tract and the CNS, however, the majority of measles-associated morbidity/mortality is due to MV immunosuppression. In MV host entry, accession of CD150+ dendritic cells (DCs) is the key to respiratory tract uptake, trafficking to lymphoid tissue and subsequent transfer to lymphocytes for dissemination. In liquid cultures, MV transmission to T cells relies on the formation of synaptic DC/T cell interfaces (virological synapses, VS). The group of Sibylle Schneider-Schaulies addresses 1) the individual role of the VS concentrated receptors in transmission, and 2) the role of actin dynamics. Subsequently, they utilize 3D collagen matrix models to monitor dynamic DC/T cell interactions. In host exit, MV appears to infect respiratory epithelial cells most likely from the basolateral side. It is believed, that transmission occurs from infected immune cells. Co-cultures of infected donor immune cells with primary bronchus epithelial cells are used to study MV transmission (cooperation with Roy Gross/Maria Steinke). More of a challenge will be to supplement the engineered human airway 3D mucosa model, which will be established within the Gross/Steinke project, with the respective infected immune cell donor population. However, based on their research experience, this model can be extended to support inclusion of these cells also into other 3D models in the consortium (collaboration with Andreas Beilhack).