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Deutsch Intern
Rudolf Virchow Center for Experimental Biomedicine

Tessmer Group

About the Tessmer Group

DNA is damaged continuously by agents that occur naturally within our cells as well as by exogenous factors such as high-energy radiation. In addition to the diverse damage introduced into previously ”healthy” DNA, the replication process itself causes errors in the genetic code (for instance base-base mis-pairs). If unrepaired, such damage and errors in the DNA can lead to cell death or diseases such as cancers. To maintain genomic stability, a number of DNA repair mechanisms have evolved, such as base-excision repair (BER), nucleotide-excision repair (NER), recombinational repair, mismatch repair (MMR), and direct damage reversal. These DNA repair systems each target different types of DNA damage and many of them are evolutionary conserved.

Single molecule studies of DNA repair

We use atomic force microscopy (AFM) in combination with other biophysical and biochemical techniques to study protein-DNA complexes involved in DNA repair. AFM enables us to directly visualize molecular assemblies at the level of the individual molecules. We are particularly interested in understanding the different DNA damage recognition strategies developed by the various DNA repair mechanisms. A second focus in our laboratory is the advancement of AFM to allow access to increased information on the sample. In this context, we are developing a combined fluorescence-AFM system for high resolution imaging of multi-protein complexes. 

Here all publications can be found

Disha Mohan Bangalore

Doktorandin
Universität Würzburg
Josef-Schneider-Str.2
97080 Würzburg
Deutschland
Building: D15
Phone: +49 931 31-81987

PD Dr. Ingrid Tessmer

Gruppenleiterin
Rudolf-Virchow-Zentrum für Experimentelle Biomedizin, Early Independence Program
Universität Würzburg
Josef-Schneider-Str.2
97080 Würzburg
Deutschland
Building: Haus D15
Room: 00.020
Phone: +49 931 31-80425
Fax: +49 931 31-87320
ORCID: https://orcid.org/0000-0002-8353-6315

Current position

Group leader, University of Würzburg, Germany (since 2014)

Research Experience

2008-2013 Early Independence Program, University of Würzburg, Germany
2007-2008 Postdoctoral Researcher, University of Würzburg, Germany
2003-2007 Postdoctoral Fellow, University of North Carolina (UNC), USA

Education

2014-2017 Habilitation in Biophysics (German eligibility for professorship) Department of Biology, University of Würzburg, Germany
1999-2003 PhD in Biophysics, University of Nottingham, UK

Position

  • Graduate School of Life Sciences
  • Faculty of Biology
  • Supervisor and Member in thesis committees

Courses

  • Biophysik und molekulare Biotechnologie (fuer Masterstudenten, Vorlesungsverzeichnis # 129350, Beitraege) SS 2019
  • Biophysik und Biochemie (fuer Masterstudenten, Vorlesungsverzeichnis # 129351, Beitraege) WS 2019/20
  • Literaturseminar DNA Reparatur (fuer Masterstudenten und Doktoranden) WS 2019/20
  • Studienbegleitende Mitarbeiten im Forschungslabor (fuer Bachelor- und Masterstudenten) WS 2019/20
  • Seminar fuer Doktoranden, Master- und Bachelorstudenten WS 2019/20
  • Anleitung zum selbststaendigen wissenschaftlichen Arbeiten WS 2019/20