Discoveries in medicine and biosciences are frequently stimulated by the invention of new scientific tools. One of these fascinating tools is fluorescence microscopy, today an integral part of life sciences.
Our group develops such tools that improve spatial and temporal resolution in multi-dimensional fluorescence imaging ─ from the single molecule to the whole organ
For whole organ imaging we interweave in vivo, in vitro and in silico concepts by combining two-photon intravital microscopy, light-sheet microscopy and computational simulations. Here, we can elucidate cell-cell or cell-vessel interactions underlying thrombopoiesis, thrombus formation or immune response.
For the (live) cell single molecule imaging we combine high-resolution concepts of fluorescence microscopy with tricks from physics and material sciences. Here, we design and nanofabricate biocompatible thin-film coatings that can serve as modified microscope substrates for faster high- and superresolution imaging of biological surfaces. Suitable for live cell applications, this approach offers the fascinating prospect of observing individual biomolecules and their interactions to learn about the underlying cellular process
1 -4 Jul 2019
See you at the Microscience Microscopy Congress 2019 (mmc2019) at Manchester Central, UK. Katrin Heinze is invited to present recent work of her lab and will talk about "Lessons From The Glassy Bone: Spatial Regulation Of Thrombopoiesis In The Bone Marrow“ in the session „Frontiers: Light sheet microscopy - Imaging complex biological samples in time and space“
13 -17 Apr 2019
See you at the FOM2019 (Focus on Microscopy) conference! The Heinze Lab presents microscopy work from the cellular to the single molecule level. Congratulations to Hannah Heil and Ashwin Balakrishnan who where selected to give a talk.
16 Feb 2019
Welcome Deyan Nestorov! PhD candidate Deyan Nestorov works on mirror-enhanced fluorescence and will develop new concepts to further boost superresolution imaging and spectroscopy to decipher receptor dynamics and interactions.
6 Dez 2018
Benjamin Schreiber successfully defended his PhD thesis, and left the group to accept a position with Carl Zeiss Meditec AG in Berlin. We thank him for his outstanding work, and wish him all the best for his future career!
8 Dez 2018
New collaborative project funded.
Together with cardiologists Anna Frey, Gustavo Ramos and neuroscientist Phillip Tovote, we secured funding from the Comprehensive Heart Failure Center (CHFC) for a 18-month start-up project on cardiac optogenetics. We are seeking surgically skilled people to try novel approaches in establishing the technology in freely moving mice. More information: https://www.defense-circuits-lab.com/
1 Okt 2018
Welcome Max Aigner! MD candidate Max Aigner works on a new superresolution imaging concept named Expansion Microscopy to understand blood platelet receptor interactions.
11 Jun 2018
Welcome Dr. Katherina Hemmen! Katherina will support computational image analysis in our imaging facility and is waiting for your exciting projects.
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11 - 16 Mar 2018
See you at the Frühjahrstagung of The Deutsche Physikalische Gesellschaft (DPG) in Berlin. Benjamin Schreiber was selected to give a talk in the session “Bioimaging and Biopspectroscopy II” (Fachverband Biologische Physik BP 23). He will talk about enhanced fluorescence resonance energy transfer in G protein-coupled receptor probes by nano-coated microscopy coverslips
17 - 21 Feb 2018
See you at the Annual Meeting of the Biophysical Society! Graduate student Hannah Heil and Katrin Heinze will be there! Congratulations to Hannah who was selected to give a Rapid Fire Talk in the Biological Fluorescence subgroup.
5 Jan 2018
Graduate student Hannah Heil was invited to give a talk during the 53rd Winterseminar in Klosters (Switzerland) in January 2018. She presented her new superresolution concept BOOSTorm.
1 Jan 2018
Oguzhan Angay left the group to accept a positon with Zeiss in Munich. We thank him for his outstanding work, and wish him all the best for his future career!
Hannah S. Heil, Benjamin Schreiber, Ralph Götz, Monika Emmerling, Marie-Christine Dabauvalle, Georg Krohne, Sven Hoefling, Martin Kamp, Markus Sauer, Katrin G. Heinze: Sharpening emitter localization in front of a tuned mirror; Light: Science and Applications; December 2018; DOI: https://doi.org/10.1038/s41377-018-0104-z
Schreiber, Benjamin; Kauk, Michael; Heil, Hannah; Emmerling, Monika; Tessmer, Ingrid; Kamp, Martin; Höfling, Sven; Holzgrabe, Ulrike; Hoffmann, Carsten; Heinze, Katrin: Enhanced fluorescence resonance energy transfer in G protein-coupled receptor probes by nano-coated microscopy coverslips; ACS Photonics, March 2018, DOI: 10.1021/acsphotonics.8b00072
Stegner D, vanEeuwijk JMM, Angay O, Gorelashvili MG, Semeniak D, Pinnecker J, Schmithausen P, Meyer I, Friedrich M, Dütting S, Brede C, Beilhack A, Schulze H, Nieswandt B, Heinze KG. Thrombopoiesis is spatially regulated by the bone marrow vasculature. Nat Commun. 2017 Jul 25;8(1):127. doi: 10.1038/s41467-017-00201-7.
Angay O, Friedrich M, Pinnecker J, Hintzsche H, Stopper H, Hempel K, Heinze KG. Image-based modeling and scoring of Howell-Jolly Bodies in human erythrocytes. Cytometry A. 2017 May. doi: 10.1002/cyto.a.23123. [Epub ahead of print]
Elsayad K, Urich A, Tan PS, Nemethova M, Small JV, Unterrainer K, Heinze KG. Spectrally coded optical nanosectioning (SpecON) with biocompatible metal-dielectric-coated substrates. Proc Natl Acad Sci U S A. 2013 Dec 10;110(50):20069-74. doi:10.1073/pnas.1307222110. Epub 2013 Nov 25. PMID:24277837
Professor of Molecular Microscopy at the Rudolf Virchow Center of the University of Würzburg (since May 2017)
|2011-2017||Group Leader at the Rudolf Virchow Center (RVZ) of the University of Würzburg, Germany|
|2006-2010||Head of the Optical Engineering Group, Independent staff scientist at the Research Institute of Molecular Pathology (IMP), Vienna, Austria|
|2004-2006||Postdoctoral Fellow at the McGill University with Prof. Dr. Wiseman and Prof. Dr. De Koninck*, Montreal, QC, Canada, *Laval University, Quebec City, QC, Canada|
|2002-2004||Postdoctoral Fellow at the Dresden University of Technology/Max-Planck-Institute of Molecular Cell Biology and Genetics with Prof. Dr. Schwille, Dresden, Germany|
2002 Ph.D. in Physics (“summa cum laude”), graduation from C.-v.-Ossietzky-University Oldenburg, Germany
- Postdoctoral Fellow of the Max-Planck Society, Germany (2004-2005)
- Picoquant Student Award for the ‘Best Student Talk’, 7th international workshop on ‘Single Molecule Detection and Ultra-Sensitive Analysis in the Life Sciences’, Picoquant, Berlin, Germany, annually awarded (2002)
- Otto-Hahn-Medal for the ‘development of high-sensitive methods for intracellular analysis of biomolecular interactions’, Max Planck Society, Hamburg, Germany, annually awarded for outstanding scientific achievements (2002)
Further training & research
- Research stay with Prof. Dr. Waxham at theUniversity of Texas Medical School, Houston, TX, USA; Research project: Establishing an instrumental platform for single molecule detection(2002)
- Carl-Zeiss, Oberkochen, Germany, dept. semiconductor technology; Research project: Nonlinear optical properties of single CaF2 crystals (1997-1998)
- Instituto Canario de Ciencias Marinas (ICCM), Telde, Spain, including a scientific ship expedition (one week), Atlantic Ocean; Research project: Fluorescence spectroscopy of Sea Water(1997)
Member - Graduate School of Life Sciences
Supervisor und Member of different promotion committees - Graduate School of Life Sciences/Biomedicine
Courses can be found here.
03980151 Für Biomediziner Literaturseminar (englisch) WS 2017/18
03980160 Literaturseminar "Microscopy Journal Club" für wissenschaftliche Mitarbeiter WS 2017/18
03980610 Seminar für Diplomanden und Doktoranden WS 2017/18
03984000 Grundlagen der computergestützten Bildverarbeitung und Analyse in der modernen Lichtmikroskopie WS2017/18
03984010 Bildgebende Verfahren in den Lebenswissenschaften WS 2017/18
03988160 Literaturseminar für wissenschaftliche Mitarbeiter WS 2017/18
03988180 Einführung in lichtmikroskopische Untersuchungen mittels Fluoreszenz für Doktoranden / Diplomanden WS 2017/18
03988190 Analyse und Auswertung von 3D-Bildstapeln für Doktoranden/Diplomanden WS 2017/18
03988410 Fluoreszenzverfahren in der Biomedizin WS 2017/18
03990910 Molekularbiologisches Methodenpraktikum - Rudolf-Virchow-Zentrum.