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Rudolf Virchow Center for Integrative and Translational Bioimaging

Press Archive

Press Archiv

Microscopy showing the fragmentation of mitochondria

Dormant herpesviruses induce their reactivation via a previously unknown cellular mechanism mediated by a viral microRNA. Würzburg researchers show this in the journal "Nature".

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The RVZ, like Rudolf Virchow, is celebrating an anniversary this year - it has been there for 20 years! From the very beginning, we have been engaged in thematically broad cutting-edge research.

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Dr. Gerti Beliu has started a new research group at the Rudolf Virchow Center of the University of Würzburg in September. He uses novel techniques to exploit the resolution of microscopy more effectively and to develop new applications for biomedicine.

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Professor David Stegner recently accepted the professorship of Vascular Imaging at the Rudolf Virchow Center. With his group, he studies the interactions of blood platelets with immune cells and how these affect inflammatory processes such as stroke.

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Poxviruses have found a unique way of translating their genes into proteins in the infected organism. A team of researchers from Würzburg shows for the first time how the molecular machinery involved works at an atomic level.

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mRNA plays a key role in the conversion of genetic information from DNA to proteins. Their production is a delicate process. A research team at the University of Würzburg has now identified a crucial factor.

 

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Dr. Tamara Girbl in her laboratory at the Rudolf Virchow Center.

Dr. Tamara Girbl started her new research group at the Rudolf Virchow Center of the University of Würzburg in April. She focuses on the interaction of immune cells and blood vessels, which plays an important role in many inflammatory diseases or even strokes.

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Dr. Hans Maric has received one of the German Research Foundation's highly prestigious Emmy Noether awards, worth around 1.7 million euros. He will use his biochip technology to study a so far unexplored group of brain proteins and determine their potential to cure so far untreatable mental diseases.

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An undesirable effect can occur in super-resolution fluorescence microscopy: photoblueing. A new publication in „Nature Methods“ shows how it can be prevented or made useful for research.

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Protein interactions can now be analysed more effectively: A phenomenon called Temperature Related Intensity Change (TRIC) makes it possible to achieve high binding signal intensity even with lowest amounts of sample. Our Maric research group established the method, which can be used to study protein complexes in highly regulated networks such as DNA transcription.

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Artemisinins are pharmaceutical compounds used against the pathogen that causes malaria. However, these substances also have multiple targets in humans which may either be pharmacologically exploited or result in undesirable side effects. Recently, scientists from Würzburg have been able to elucidate one of the underlying molecular mechanisms by showing how these drugs inhibit the vitamin B6 generating enzyme in humans. The results were published in the scientific journal PNAS.

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For the first time ever, expansion microscopy allows the imaging of even the finest details of cell membranes. This offers new insights into bacterial and viral infection processes.

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