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Deutsch Intern
Rudolf Virchow Center for Integrative and Translational Bioimaging

Press Archive

Press Archiv

A cancer shredder

09/29/2020

Researchers at the universities of Würzburg and Frankfurt have developed a new compound for treating cancer. It destroys a protein that triggers its development.

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The previously largely unknown molecule bridging integrator 2 (BIN2) plays a central role in platelet activation, as researchers from Würzburg have now shown in a joint project of the DFG Collaborative Research Centre / Transregio 240. This finding provides indications of starting points for drug development against thrombosis, heart attack and stroke and was published in the renowned journal The Journal of Clinical Investigation.

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Using a newly developed method, researchers from the University of Würzburg, in cooperation with the University Hospital of Würzburg, were able to identify thousands of special peptides on the surface of cells for the first time. They were able to show that these so-called cryptic peptides mark a significant proportion of tumor cells. These findings could provide a new starting point for cancer immunotherapy and were published in the renowned journal Cancer Immunology Research.

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Die Hauptprotease (grün) ist ein wichtiges Molekül, das dem Virus bei der Vermehrung hilft. Mit einem geeigneten Medikament (hier in rot als Stabmodell) könnte das Molekül in seiner Funktion gehemmt werden.

Dr. Andrea Thorn, a structural biologist from Würzburg, is leading an international coronavirus research network. The results of her work are important for developing vaccines and drugs.

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Tuberculosis is a highly contagious infectious disease that is typically spread through aerosols and mainly affects the lungs. Every year, an estimated 1.7 million people worldwide die from such an infection.

Researchers at the University of Würzburg and the Spanish Cancer Research Centre have gained new insights into the pathogen that causes tuberculosis. The work published in Nature provides the basis for a new approach in antibiotic therapy.

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Visualizing specific structures over background fluorescence can be challenging. The Wehman lab has developed a labeling technique based on selective degradation that allows super-resolution insights on standard microscopes, improving the imaging of specific proteins, organelles, and cells in many model systems. The project has been published in Nature Communications.

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Dr. Hardikkumar Jetani (Mitte) mit dem Promotionskomitee und Vertreterinnen der Graduate School (v.l.): Prüfungsvorsitzender Professor Thomas Rudel, Professor Thomas Herrmann, PD Dr. Friederike Berberich-Siebelt, Dr. Michael Hudecek, Dr. Gabriele Blum-Oehler, Professorin Caroline Kisker.

PhD student Hardikkumar Jetani has a round number to his name: he is the 500th doctoral researcher in the Graduate School of Life Sciences (GSLS) to successfully defend his thesis.

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Researchers from the Rudolf Virchow Center of the University of Würzburg (JMU) have solved the structures of the cancer-promoting enzymes USP25 and USP28, and identified significant differences in their activities. Both enzymes promote the growth of various tumors. The results were published in the journal Molecular Cell and could benefit towards the development of new, low-side-effects anticancer drugs.

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Mirrored slides now allow significantly sharper images / 20x better resolution than an ordinary light microscope - Scientists at the University of Würzburg have been able to boost current super-resolution microscopy by a novel tweak. They coated the glass cover slip as part of the sample carrier with tailor-made biocompatible nanosheets that create a "mirror effect". This method shows that localizing single emitters in front of a metal-dielectric coating leads to higher precision, brightness and contrast in Single Molecule Localization Microscopy (SMLM). The study was published in the Nature journal "Light: Science and Applications".

 

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