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Rudolf Virchow Center for Experimental Biomedicine

Press Archive

Press Archiv

Tuberkulose ist eine hochansteckende Infektionskrankheit, die über den Luftweg übertragen wird und hauptsächlich die Lunge befällt. Jedes Jahr sterben geschätzte 1,7 Millionen Menschen weltweit daran.

Researchers at the University of Würzburg and the Spanish Cancer Research Centre have gained new insights into the pathogen that causes tuberculosis. The work published in Nature provides the basis for a new approach in antibiotic therapy.

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Researchers from the Rudolf Virchow Center of the University of Würzburg (JMU) have solved the structures of the cancer-promoting enzymes USP25 and USP28, and identified significant differences in their activities. Both enzymes promote the growth of various tumors. The results were published in the journal Molecular Cell and could benefit towards the development of new, low-side-effects anticancer drugs.

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Das Enzym PKD1 scheint eine zentrale Rolle im Fettstoffwechsel zu übernehmen. Das konnten Wissenschaftler des Rudolf-Virchow-Zentrums der Universität Würzburg nun in einer neuen Studie zeigen. Mäuse, denen das Enzym fehlte, blieben auch bei kalorienreicher Ernährung schlank. Beim Menschen scheint PKD1 ähnlich zu wirken. Möglicherweise weisen die Ergebnisse daher den Weg zu neuen Medikamenten gegen Fettleibigkeit und Diabetes.

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Zum ersten Mal veranstaltete BioM das FORUM Translational Medicine in Würzburg - die Auftaktveranstaltung einer zweijährlich geplanten Reihe mit besonderem Schwerpunkt auf die hervorragende wissenschaftliche Forschung an diesem Standort.

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Mirrored slides now allow significantly sharper images / 20x better resolution than an ordinary light microscope - Scientists at the University of Würzburg have been able to boost current super-resolution microscopy by a novel tweak. They coated the glass cover slip as part of the sample carrier with tailor-made biocompatible nanosheets that create a "mirror effect". This method shows that localizing single emitters in front of a metal-dielectric coating leads to higher precision, brightness and contrast in Single Molecule Localization Microscopy (SMLM). The study was published in the Nature journal "Light: Science and Applications".

 

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Folding poisons

09/12/2018

Researchers show how toxins of the bacterium Clostridium difficile get into cells in the gut

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Gratulanten und Nutznießer des Neubaus der Graduiertenschule für die Lebenswissenschaften. (Foto: Corinna Russow)

Mit einem Festakt und vielen Ehrengästen hat die Julius-Maximilians-Universität Würzburg das neue Gebäude der Graduate School of Life Sciences auf dem Hubland-Campus Nord eingeweiht.

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Targeting platelets

05/24/2018

A new Collaborative Research Center will start in July with a total funding of nearly 14 million euros, headed by the German Institute for Experimental Biomedicine in Würzburg. The aim is to decode the complex and insufficiently understood functions of platelets, the so-called thrombocytes. The scientists hope to use these findings to gain new insights into platelet research which allow better treatment of conditions such as heart attack, stroke, acute lung failure and cancer.

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Das Bild zeigt ein Deckglas und dessen Spiegeleffekt mit Goldbeschichtung

G protein-coupled receptors (GPCRs) are the major target molecules for drug discovery. Scientists at the University of Würzburg and the University Hospital Jena have now been able to explore the activation of these receptors in more detail by developing a modern microscopy technique. Increasing the Förster Resonance Energy Transfer (FRET) through the use of specially coated coverslips was the key.

 

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Foto von Dr. Hans Michael Maric im Labor

Since January Dr. Hans Michael Maric is a new group leader at the Rudolf Virchow Center of the University of Würzburg. His research focuses on the development of new drugs based on microarrays.

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Bettina Böttcher vor Elektronenmikroskop

This year, one of the world's most powerful electron microscopes will start operation at the University of Würzburg, providing images of biological molecules of unparalleled quality.

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