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Rudolf Virchow Center for Integrative and Translational Bioimaging

Press Releases

Below you can find the press releases of the Rudolf Virchow Center:

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Artemisinins are pharmaceutical compounds used against the pathogen that causes malaria. However, these substances also have multiple targets in humans which may either be pharmacologically exploited or result in undesirable side effects. Recently, scientists from Würzburg have been able to elucidate one of the underlying molecular mechanisms by showing how these drugs inhibit the vitamin B6 generating enzyme in humans. The results were published in the scientific journal PNAS.

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For the first time ever, expansion microscopy allows the imaging of even the finest details of cell membranes. This offers new insights into bacterial and viral infection processes.

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The protein complex TFIIH is responsible for essential cellular functions such as transcription or DNA repair. These processes must be carried out with extreme precision in order to prevent serious diseases, such as cancer. The enzyme XPB is part of the TFIIH complex and is indispensable for both processes. How XPB is simultaneously activated and repressed by its interaction partners p8/p52 within the TFIIH complex has now been demonstrated by a Würzburg research group. The results improve the functional understanding of this intricate complex and were published in the journal Nucleic Acids Research.

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New complex for damage detection in DNA identified.

 

Our body can repair damage to our DNA that can lead to the development of cancer by means of repair complexes. But how does the repair machinery recognize the damage? Scientists from the University of Würzburg and the University of Kent have now identified a complex that plays an important role in damage recognition in nucleotide excision repair. Due to its key position, the complex represents a starting point for research on cancer drugs. The results were published in the renowned journal Nucleic Acids Research.

 

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In stress situations, bacteria use special ion channels for defense. Understanding how they function provides the basis for combating harmful bacteria. A Würzburg research group in cooperation with ETH Zurich and the University of Oxford has now been able to decipher how two of these channels are structured and how they open up. The results were published in the renowned journal PNAS.

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