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Dual-Acting Cholinesterase–Human Cannabinoid Receptor 2 Ligands Show Pronounced Neuroprotection in Vitro and Overadditive and Disease-Modifying Neuroprotective Effects in Vivo

M. Scheiner et al.
J. Med. Chem. 2019, 62, 20, 9078-9102
doi: 10.1021/acs.jmedchem.9b00623

Copyright © 2019 ACS

Novel insight in estrogen homeostasis and bioactivity in the ACI rat model of estrogeninduced mammary gland carcinogenesis

D. Pemp, H.L. Esch, R. Hauptstein, F.J. Möller, O. Zierau, M.C. Bosland, L.N. Geppert, C. Kleider, K. Schlereth, G. Vollmer, L. Lehmann
Arch. Toxicol. 2019 Jul;93(7):1979-1992

doi: 10.1007/s00204-019-02483-w

Copyright © 2019 Springer Nature Switzerland AG (Part of Springer Nature. B.V.)

Highly Selective Butyrylcholinesterase Inhibitors with Tunable Duration of Action by Chemical Modification of Transferable Carbamate Units Exhibit Pronounced Neuroprotective Effect in an Alzheimer’s Disease Mouse Model

M. Hoffmann et al.
J. Med. Chem. 2019, 62, 20, 9116-9140

doi: 10.1021/acs.jmedchem.9b01012

© 2019 ACS

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