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    Weibchen der Tigermücke (Aedes aegyptii) sticht in die Haut eines Menschen. (Foto: US Department of Health and Human Services / Wikimedia Commons)

    Just like Ebola, dengue fever can be fatal. This disease is also caused by a virus for which there is currently no cure and no vaccine. Researchers from Mainz and Würzburg are now proposing potential new active substances.

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    Die Abbildungen zeigen die Folgen von Mutationen im USP8-Gen, die zu einer Überproduktion von Adrenocorticotropin (ACTH) Cushing-Adenomen der Hirnanhangsdrüse führen. (A) zeigt ACTH-produzierende Zellen in der normalen Hypophyse; (B) den USP8-Wildtyp (

    Benign tumors in the pituitary gland are responsible when adrenal gland cells secrete the stress hormone cortisol unchecked. An international team of scientists has now succeeded in mapping out in detail the molecular processes that lie behind this.

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    Wechselwirkung des Steroids (gelb) mit dem Enzym FadA5 des Tuberkulose-Erregers. Das Steroid bietet eine gute Basis für die Entwicklung eines neuen Hemmstoffs. (Bild: Caroline Kisker)

    Researchers from Würzburg and Stony Brook have found a new weak spot in the bacterium that causes tuberculosis: Blocking a specific enzyme involved in the cholesterol catabolism could disable the bacteria.

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    Auswirkung der Proteinkinase A (PKA) Mutationen. Durch die Mutation der „katalytischen“ Untereinheit (C) wird die Bindung der "regulatorischen" (R) und somit deren Kontrolle über die "katalytische" Untereinheit gehemmt. Dies führt zu einer unkontrol

    The mutation of a key enzyme results in the secretion of abnormally high levels of cortisol in the adrenal gland. A group of researchers led by Martin Lohse and Davide Calebiro from the Rudolf Virchow Center at the University of Würzburg have now succeeded in mapping out the precise mechanisms. They report on this in the online journal “Nature Communications”.

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    Die Professoren Virima Mudogo (links) und Gerhard Bringmann wurden gemeinsam mit dem Gusi Peace Prize geehrt (Foto: Thomas Waldner)

    The Gusi Foundation has awarded the Gusi Peace Prize to the professors Gerhard Bringmann (Würzburg) and Virima Mudogo (Kinshasa) and has thus honored them for their scientific achievements in the search for bioactive compounds and for their humanitarian merits for young academics in the Congo.

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    One year in space

    11/21/2014
    Der Würzburger Uni-Satellit UWE-3 ist schon ein Jahr im Weltraum und funktioniert immer noch. (Foto: Lehrstuhl für Informatik VII)

    UWE-3, the satellite developed by the University of Würzburg, is a technical marvel: On November 21, it has been in space for exactly a year – and it is still functioning perfectly. This is an extraordinary feat given the harsh conditions in outer space.

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    MAGIC-Teleskope auf La Palma (Foto: Dr. Daniela Dorner)

    It was an extraordinary spectacle in the Perseus galaxy cluster: An international team of astrophysicists detected an exceptional flare in the gamma-ray spectrum during observations of galaxy IC 310. This meant that particles had been accelerated to extremely high energies in a very small space.

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    Tricky invaders

    10/30/2014
    Chlamydien inaktivieren p53 und wachsen in großen Einschlüssen (rot) in ihren Wirtzellen (blau) (linkes Foto). Künstlich stabilisiertes p53 (grün) verhindert die Infektion mit Chlamydien (rechtes Foto). (Bild: C. Siegl et al., 2014)

    Chlamydia are the triggers for a whole range of serious diseases. At the same time, the bacteria are dependent for their survival on support from the cells they attack. The tricks they use here have been examined more closely by microbiologists from the University of Würzburg.

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    Professor Rainer Hedrich (Foto: Gunnar Bartsch)

    The progressive salinisation of soils is becoming increasingly problematic for farming, jeopardising the supply of a growing world population. Scientists from Germany and Australia are sounding alarm over this development, calling for new efforts to breed salt-tolerant crops.

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    Dr. Tobias Langenhan, Leiter der neuen DFG-Forschergruppe „Elucidation of Adhesion-GPCR Signaling“. (Foto: Gunnar Bartsch)

    They are termed adhesion G protein-coupled receptors. These receptors are involved in a wealth of vital functions in the body and therefore represent a promising target for drugs, yet relatively little is known about how they work. A new research unit is keen to change this.

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    Laurens Molenkamp, ein vielfach ausgezeichneter Physiker. (Foto privat)

    Würzburg physicist Professor Laurens Molenkamp has been honoured as "Thomson Reuters Citation Laureate" in recognition of his highly impactful work that receives broad attention in the scientific world.

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    Die eigene Hand verdeckt, die Puppenhand gut sichtbar darüber – und beide werden synchron mit einem Pinsel gestreichelt: So sieht das klassische „Rubber-Hand-Illusion-Experiment“ aus. (Foto: AG Zeller)

    What does the brain do when it receives information from they eye that conflicts with sensory evidence from the hand? Neurologists from Würzburg have investigated this question by means of a classical experiment. The result: The brain takes the easy route.

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    Die MAP-Kinase p38 wird in den Uhren-Neuronen im Gehirn der Taufliege exprimiert und ist nachts aktiv (links unten). Sie interagiert mit dem Uhren-Protein Period und verbindet auf diese Weise das Stress-System mit der inneren Uhr. Rechts oben ist das neur

    There are two phenomena which basically determine the lives of all organisms: the continuous day-and-night cycle and the occurrence of sudden events. To respond adequately to this, organisms have developed special mechanisms that have one surprising thing in common.

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    Blattporen mit ihren charakteristischen bohnenförmigen Schließzellen (A). Rechts ist schematisch der Mechanismus gezeigt, mit dem Pflanzen bei Trockenheit die Poren schließen. (Bild: Dietmar Geiger)

    Growing crops with better drought tolerance capable of withstanding climate change: That is the goal the Würzburg plant researchers are pursuing. They describe the latest progress of their research in the journal "Science Signaling".

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    (A) Gezeigt ist die Struktur eines Channelrhodopsin-Ionenkanals relativ zum Intra- und Extrazellularraum. In der neuen Channelrhodopsin-Mutante (ChR2-XXL) ist an Stelle einer Asparaginsäure an Position 156 (Pfeil) ein Cystein (D156C). (B) Die deutlich ve

    Special ion channels make it possible: Neurons can be activated and deactivated purposefully using light. Scientists from the University of Würzburg have now significantly improved these channels, making it easier than ever before to examine complex patterns of behavior.

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