Intern
    Institut für Anatomie und Zellbiologie

    Detlev Drenckhahn

       
    • Emeritus
    •  
    • Beauftragter für die Ärztliche Vorpüfung der Julius-Maximilians-Universität
    •  


    Institut für Anatomie
    und Zellbiologie
     
    Koellikerstr. 6
    D-97070 Würzburg
     
    Tel. +49 931 31 82702
    Fax +49 931 31 82712
     
    email
     
       
     
    Forschungsinteresse:    

    Herz-Kreislauf-Forschung

    Herausgeberschaften:

       

    > Histochemistry and Cell Biology
    > Lehrbuch der Anatomie, Embryologie und Histologie (begründet von
       A. Benninghoff), Urban & Fischer Verlag, Elsevier
    > Taschenbuch Anatomie, Urban & Fischer Verlag, Elsevier
    > Forum Geobotanicum - An Electronic Journal of Geobotanical
       Research
     

    Mitgliedschaften:

        Ehrenmitglied der Humboldt-Universität zu Berlin
    Senat der Deutschen Akademie der Naturforscher Leopoldina
    World Wide Fund for Nature (WWF), Präsident
    Institut für Medizinisch-Pharmazeutische Prüfungsfragen
     

    Persönliche Interessen:

        Ökologie / Naturschutz
     

    Ausgewählte Publikationen

    Drenckhahn, D., Gröschel-Stewart, U.: Localization of myosin, actin, and tropomyosin in rat intestinal epithelium. Immunocytochemical studies at the light- and electron microscopic levels.
    J. Cell Biol. 86, 475-482 (1980)

    Drenckhahn, D., Kellner, J., Mannherz, H.G., Gröschel- Stewart, U., Kendrick-Jones, J., Scholey, J.: Absence of myosin-like immunoreactivity in stereocilia of cochlear hair cells.
    Nature 300, 531-532 (1982)

    Franke, R.-P., Gräfe, M., Schnittler, H., Seiffge, D., Mittermayer, C., Drenckhahn, D.: Induction of human vascular endothelial stress fibres by fluid shear stress.
    Nature 307, 648-649 (1984)

    Low, P.S., Waugh, S.M., Zinke, K., Drenckhahn, D.: The role of hemoglobin denaturation and band 3 clustering in red blood cell aging.
    Science 227, 531-533 (1985)

    Drenckhahn, D., Schlüter, K., Allen, D.P., Bennett, V.: Colocalization of band 3 with ankyrin and spectrin at the basal membrane of intercalated cells in the rat kidney.
    Science 230, 1281-1289 (1985)

    Drenckhahn, D., Wagner, H.J.: Stress fibres in the splenic sinus endothelium in situ: Molecular structure, relationship to the extracellular matrix, contractility.
    J. Cell Biol. 102, 1738-1747 (1986)

    Drenckhahn, D., Franz, H.: Identification of actin, alpha-actinin, and vinculin-containing plaques at the lateral membrane of epithelial cells.
    J. Cell Biol. 102, 1943-1952 (1986)

    Drenckhahn, D., Pollard, T.D.: Elongation of actin filaments is a diffusion-limited reaction at the barbed end and is accelerated by inert molecules.
    J. Biol. Chem. 261, 12754-12758 (1986)

    Schlüter, K., Drenckhahn, D.: Co-clustering of denatured hemoglobin with band 3: Its role in binding of autoantibodies against band 3 to abnormal and aged red blood cells.
    Proc. Natl. Acad. Sci. USA 83, 6137-6141 (1986)

    Wagner S., Vogel, R., Lietzke, R., Koob, R., Drenckhahn, D.: Immunochemical characterization of a band 3-like anion exchanger in the collecting duct of the human kidney.
    Am. J. Physiol. 253, F213-D221 (1987)

    Koob, R., Zimmermann, M., Schoner, W., Drenckhahn, D.: Colocalization and coprecipitation of ankyrin and Na+,K+-ATPase in kidney epithelial cells.
    Eur. J. Cell Biol. 45, 230-237 (1987)

    Drenckhahn, D., Franke, R.-P.: Ultrastructural organization of contractile and cytoskeletal proteins in glomerular podocytes of chicken, rat, and man.
    Lab. Invest. 59, 673-682 (1988)

    Drenckhahn, D., Dermietzel, R.: Organization of the actin filament cytoskeleton in the intestinal brush border: A quantitative and qualitative immunoelectron microscope study.
    J. Cell Biol. 107, 1037-1048 (1988)

    Kraemer, D., Koob, R., Friedrichs, B., Drenckhahn, D.: Two novel peripheral membrane proteins, pasin 1 and pasin 2, associated with Na+,K+-ATPase in various tissues.
    J. Cell Biol. 111, 2375-2383 (1990)

    Schnittler, H., Wilke, A., Gress, T., Suttorp, N., Drenckhahn, D.: Role of actin and myosin in the control of paracellular permeability in pig, rat and human vascular endothelium.
    J. Physiol. 431, 379-401 (1990)

    Nehls, V., Drenckhahn, D.: Heterogeneity of microvascular pericytes for smooth muscle alpha-actin.
    J. Cell Biol. 113, 147-154 (1991)

    Drenckhahn, D., Engel E., Höfer, D., Merte, C., Tilney, M., Tilney, L.: Three different actin filament assemblis occur in every hair cell: Each contains a specific actin cross linking protein.
    J. Cell Biol. 112, 641-651 (1991)

    Jöns, T., Drenckhahn, D.: Identification of the binding interface involved in linkage of cytoskeletal protein to the erythrocyte anion exchanger.
    EMBO J. 11, 2863-2867 (1992)

    Kugler, P., Drenckhahn, D.: Intrinsic source of stomach NO.
    Nature 370, 25-26 (1994)

    Alper, S.L., Stuart-Tilley, A., Simmons, C.F., Brown, D., Drenckhahn, D.: The fodrin-ankyrin cytoskeleton of choroid plexus preferentially colocalizes with apical Na+, K+-ATPase rather than with basolateral anion exchanger AE2.
    J. Clin. Invest. 93, 1430-1438 (1994)

    Nehls, V., Drenckhahn, D.: A microcarrier-based cocultivation system for the investigation of angiogenesis in a three-dimensional fibrin matrices in vitro.
    Histochem. Cell Biol. 104, 459-466 (1995)

    Schmitz, F., Bechmann, M., Drenckhahn, D.: Purification of synaptic ribbons, structural components of the photoreceptor active zone complex.
    J. Neurosci. 16(22), 7109-7116 (1996)

    Höfer, D., Püschel, B., Drenckhahn, D.: Taste receptor-like cells in the gut identified by expression of alpha-gustducin.
    Proc. Nat. Acad. Sci. USA 93, 6631-6634 (1996)

    Höfer, D., Ness, W., Drenckhahn, D.: Sorting of actin isoforms in chicken auditory hair cells.
    J. Cell Sci. 110, 765-770 (1997)

    Kraemer, J., Schmitz, F., Drenckhahn, D.: Cytoplasmic dynein and dynactin as likely candidates for microtubule-dependent apical targeting of pancreatic zymogen granules.
    Eur. J. Cell Biol. 78, 265-277 (1999)

    Baumgartner, W., Hinterdorfer, P., Ness, W., Raab, A., Vestweber, D., Schindler, H., Drenckhahn, D.: Cadherin interaction probed by atomic force microscopy.
    Proc. Natl. Acad. Sci. USA (2000) 97: 4005-4010

    Hübner S, Jans DA, Drenckhahn D.: Roles of cytoskeletal and junctional plaque proteins in nuclear signaling.
    Int Rev Cytol. (2001) 208:207-65

    Adamson RH, Curry FE, Adamson G, Liu B, Jiang Y, Aktories K, Barth H, Daigeler A, Golenhofen N, Ness W, Drenckhahn D.
    Rho and rho kinase modulation of barrier properties: cultured endothelial cells and intact microvessels of rats and mice.
    J Physiol. 2002 Feb 15;539(Pt 1):295-308.

    Baumgartner W.; Drenckhahn D. Transmembrane cooperative linkage in cellular adhesion.
    Eur. J. Cell Biol, (2002). 81, 161-168

    Golenhofen N, Arbeiter A, Koob R, Drenckhahn D.
    Ischemia-induced association of the stress protein alpha B-crystallin with I-band portion of cardiac titin.
    J Mol Cell Cardiol. 2002 Mar;34(3):309-19.

    Baumgartner, W., Golenhofen, N., Grundhöfer, N., Wiegand, J., Drenckhahn, D.: Ca2+ dependency of N-cadherin function probed by laser tweezer and atomic force microscopy.
    J. Neurosci. 23, 11008-11014 (2003)

    Baumgartner, W., Wiegand, J., Schütz, G. J., Golenhofen, N., Drenckhahn, D.: Cadherin function probed by laser tweezer and single molecule fluorescence in vascular endothelial cells.
    J. Cell Sci. 116, 1001-1011 (2003)

    Waschke J, Baumgartner W, Adamson RH, Zeng M, Aktories K, Barth H, Wilde C, Curry FE, Drenckhahn D.
    Requirement of Rac activity for maintenance of capillary endothelial barrier properties.
    Am J Physiol Heart Circ Physiol. 2004 Jan;286(1):H394-401

    Waschke J, Drenckhahn D, Adamson RH, Curry FE.
    Role of adhesion and contraction in Rac 1-regulated endothelial barrier function in vivo and in vitro.
    Am J Physiol Heart Circ Physiol. 2004 Aug;287(2):H704-11

    Förster, C., Silwedel, C., Golenhofen, N., Burek, M., Kietz, S., Mankertz, J., Drenckhahn, D.: Occludin as direct target for glucocorticoid-induced improvement of blood brain-barrier properties.
    J. Physiol. 565, 475-486 (2005)

    Waschke, J., Bruggeman, P., Baumgartner, W., Zillikens, D., Drenckhahn, D: Pemphigus foliaceus IgG causes dissociation of desmoglein 1-containing junctions without blocking desmoglein 1 transinteraction.
    J. Clin. Invest. 115, 3157-3165 (2005)

    Foerster, C., Waschke, J., Burek, M., Leers, J., Drenckhahn, D.: Glucocorticoid effects on microvascular endothelial barrier permeability are brain specific.
    J Physiol. 573(Pt 2):413-25. (2006)

    Waschke J, Spindler V, Bruggeman P, Zillikens D, Schmidt G, Drenckhahn D.: Inhibition of Rho A activity causes pemphigus skin blistering.
    J Cell Biol. 175(5):721-7. (2006)

    Förster C, Kahles T, Kietz S, Drenckhahn D.
    Dexamethasone induces the expression of metalloproteinase inhibitor TIMP-1 in the murine cerebral vascular endothelial cell line cEND.
    J Physiol. 2007 May 1;580(Pt.3):937-49.

    Spindler V, Drenckhahn D, Zillikens D, Waschke J.
    Pemphigus IgG causes skin splitting in the presence of both desmoglein 1 and desmoglein 3.
    Am J Pathol. 2007 Sep;171(3):906-16

    Waschke J, Menendez-Castro C, Bruggeman P, Koob R, Amagai M, Gruber HJ, Drenckhahn D, Baumgartner W.
    Imaging and force spectroscopy on desmoglein 1 using atomic force microscopy reveal multivalent Ca(2+)-dependent, low-affinity trans-interaction.
    J Membr Biol. 2007 Apr;216(2-3):83-92

    Müller-Marschhausen K, Waschke J, Drenckhahn D.
    Physiological hydrostatic pressure protects endothelial monolayer integrity.
    Am J Physiol Cell Physiol. 2008 Jan;294(1):C324-32

    Heupel WM, Baumgartner W, Laymann B, Drenckhahn D, Golenhofen N.
    Different Ca2+ affinities and functional implications of the two synaptic adhesion molecules cadherin-11 and N-cadherin.
    Mol Cell Neurosci. 2008 Mar;37(3):548-58

    Blecharz KG, Drenckhahn D, Förster CY.
    Glucocorticoids increase VE-cadherin expression and cause cytoskeletal rearrangements in murine brain endothelial cEND cells.
    J Cereb Blood Flow Metab. 2008 Jun;28(6):1139-49

    Baumgartner W, Wendeler MW, Weth A, Koob R, Drenckhahn D, Gessner R.
    Heterotypic trans-interaction of LI- and E-cadherin and their localization in plasmalemmal microdomains.
    J Mol Biol. 2008 Apr 18;378(1):44-54

    Förster C, Burek M, Romero IA, Weksler B, Couraud PO, Drenckhahn D.
    Differential effects of hydrocortisone and TNFalpha on tight junction proteins in an in vitro model of the human blood-brain barrier.
    J Physiol. 2008 Apr 1;586(7):1937-49

    Heupel WM, Zillikens D, Drenckhahn D, Waschke J.
    Pemphigus vulgaris IgG directly inhibit desmoglein 3-mediated transinteraction.
    J Immunol. 2008 Aug 1;181(3):1825-34.

    Heupel WM, Efthymiadis A, Schlegel N, Müller T, Baumer Y, Baumgartner W, Drenckhahn D, Waschke J.
    Endothelial barrier stabilization by a cyclic tandem peptide targeting VE-cadherin transinteraction in vitro and in vivo.
    J Cell Sci. 2009 May 15;122(Pt 10):1616-25.

    Chtcheglova LA, Wildling L, Waschke J, Drenckhahn D, Hinterdorfer P.
    AFM functional imaging on vascular endothelial cells.
    J Mol Recognit. 2010 Nov-Dec;23(6):589-96.

    Nach oben

    Kontakt

    Institut für Anatomie und Zellbiologie
    Koellikerstraße 6
    97070 Würzburg

    Tel.: +49 931 31-82117
    E-Mail

    Suche Ansprechpartner

    Koellikerstraße 6