Stem cells are fascinating cell types both for basic research as well as for clinical applications. The Müller group is analyzing the developmental potential and molecular regulators of pluri- and multipotent stem cells. The following stem cell types are "under investigation".

Current Publications

Polycomb Protein BMI1 Regulates Osteogenic Differentiation of Human Adipose Tissue-Derived Mesenchymal Stem Cells Downstream of GSK3. Becker Matthias, Potapenko Tamara, Niklaus Andrea, Bieback Karen, Ho Anthony, Müller Albrecht. Stem Cells Dev. 2016 May 19. [Epub ahead of print]

Inhibition of KDM6 activity during murine ES cell differentiation induces DNA damage. Christine Hofstetter, Justyna M. Kampka, Sascha Huppertz, Heike Weber, Andreas Schlosser, Albrecht M. Müller, Matthias Becker, J Cell Sci 2016 : doi: 10.1242 /jcs. 175174

PRC2 inhibition counteracts the culture-associated loss of engraftment potential of human cord blood-derived hematopoietic stem and progenitor cells. Linda Varagnolo, Qiong Lin, Nadine Obier, Christoph Plass, Johannes Dietl, Martin Zenke, Rainer Claus, Albrecht M. Müller, Scientific Reports 2015 Jul 22;5:12319. doi: 10.1038 / srep 12319.

Human parthenogenetic embryonic stem cell-derived neural stem cells express HLA-G and show unique resistance to NK cell-mediated killing.Schmitt J, Eckardt S, Schlegel PG, Sirén AL, Bruttel VS, Mclaughlin KJ, Wischhusen J, Müller AM.  Mol Med. 2015 Mar 23. doi: 10.2119 / molmed. 2014.00188.

Pcgf6, a polycomb group protein, regulates mesodermal lineage differentiation in murine ES cells and functions in iPS reprogramming. Zdzieblo, D., Li, X., Lin, Q., Zenke, M., Illich, D.J., Becker, M. and Müller, A.M. Stem Cells, (2014).

PRC1-mediated gene silencing in pluripotent ES cells: function and evolution. Epigenetic Mechanisms in Cellular Reprogramming (Meissner, A., Walter, J. (Eds.)), Becker, M., Mah, N., Zdzieblo, D., Li, X., Mer, A., Andrade-Navarro M.A., and Müller, A.M. 2015, pp 141-166.

Polycomb protein EED is required for silencing of pluripotency genes upon ESC differentiation. Obier, N., Lin, Q., Cauchy, P., Hornich, V., Zenke, M., Becker, M. and Müller, A.M. Stem Cell Reviews and Reports, (2014).

Identification of Small Molecule Modulators of Gene Transcription with Anti-Cancer Activity. Tran, T.A., Wichterman-Kouznetsova, J., Varghese, D., Huang, R., Huang, W., Becker, M., Austin, C.P., Inglese, J., Johnson, R.L. and Martinez, E.D. ACS Chem. Biol. (2014) 9, 2603-2611.