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    Knäuel im Genom: Dafür interessiert sich Katrin Paeschke.   (Foto privat)

    Once again, a generous EU research grant goes to the University of Würzburg. Biochemist Katrin Paeschke is being given a renowned Starting Grant of around EUR 1.5 million for her research by the European Research Council (ERC).

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    Weibchen der Tigermücke (Aedes aegyptii) sticht in die Haut eines Menschen. (Foto: US Department of Health and Human Services / Wikimedia Commons)

    Just like Ebola, dengue fever can be fatal. This disease is also caused by a virus for which there is currently no cure and no vaccine. Researchers from Mainz and Würzburg are now proposing potential new active substances.

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    Die Abbildungen zeigen die Folgen von Mutationen im USP8-Gen, die zu einer Überproduktion von Adrenocorticotropin (ACTH) Cushing-Adenomen der Hirnanhangsdrüse führen. (A) zeigt ACTH-produzierende Zellen in der normalen Hypophyse; (B) den USP8-Wildtyp (

    Benign tumors in the pituitary gland are responsible when adrenal gland cells secrete the stress hormone cortisol unchecked. An international team of scientists has now succeeded in mapping out in detail the molecular processes that lie behind this.

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    Wechselwirkung des Steroids (gelb) mit dem Enzym FadA5 des Tuberkulose-Erregers. Das Steroid bietet eine gute Basis für die Entwicklung eines neuen Hemmstoffs. (Bild: Caroline Kisker)

    Researchers from Würzburg and Stony Brook have found a new weak spot in the bacterium that causes tuberculosis: Blocking a specific enzyme involved in the cholesterol catabolism could disable the bacteria.

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    Auswirkung der Proteinkinase A (PKA) Mutationen. Durch die Mutation der „katalytischen“ Untereinheit (C) wird die Bindung der "regulatorischen" (R) und somit deren Kontrolle über die "katalytische" Untereinheit gehemmt. Dies führt zu einer unkontrol

    The mutation of a key enzyme results in the secretion of abnormally high levels of cortisol in the adrenal gland. A group of researchers led by Martin Lohse and Davide Calebiro from the Rudolf Virchow Center at the University of Würzburg have now succeeded in mapping out the precise mechanisms. They report on this in the online journal “Nature Communications”.

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